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Human CTLA-4/CD152 ELISA Kit Distributor

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Product Details

Standard - EK1241.jpg


BrandMultiSciences
CatNum70-EK1241
ProductNameHuman CTLA-4/CD152 ELISA Kit
CustomsNameHuman CTLA-4/CD152 ELISA Kit
ApplicationELISA
ReactivityHuman
Assay TypeSandwich ELISA
Suitable Sample Typeserum, plasma, cell culture supernates
Format96-well strip plate
Storage4℃ (unopened) standard stored at -20℃, others stored at 4℃ (opened)
Shipping Condition4℃
Sample Volume50 μl
Sensitivity0.71 pg/ml
Standard Curve Range93.75 - 6000 pg/ml
Spike Recovery Range78 % - 120 %
Mean Spike Recovery0.94
CV of Intra plate2.4 % - 3.7 %
CV of Inter plate3.1 % - 4.3 %
Components96-well polystyrene microplate coated with a monoclonal antibody against CTLA-4
Human CTLA-4 Standard, lyophilized
CTLA-4 Detect Antibody
Standard Diluent
Assay Buffer (10×)
Substrate (TMB)
Stop Solution
Washing Buffer (20×)
Plate Covers
DescribtionThis assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of human CTLA-4. The Human CTLA-4/CD152 ELISA is for research use only. Not for diagnostic or therapeutic procedures.
Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), also known as CD152, is a member of the immunoglobulin superfamily that is expressed on the surface of helper T cells. CTLA-4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86. CTLA-4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. CTLA-4 functions as an immune checkpoint, downregulates the immune system, acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells. Intracellular CTLA-4 is also found in regulatory T cells and may be important to their function.
Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves' disease, Hashimoto's thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, primary biliary cirrhosis and other autoimmune diseases. Polymorphisms of the CTLA-4 gene are associated with autoimmune diseases such as autoimmune thyroid disease and multiple sclerosis, though this association is often weak. In systemic lupus erythematosus, the splice variant sCTLA-4 is found to be aberrantly produced and found in the serum of patients with active systemic lupus erythematosus.


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