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Human Fas Ligand/TNFSF6 Antibody ELISA Kit

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Product Details

Standard - EK1F02.jpg


BrandMultiSciences
CatNum70-EK1F02
ProductNameHuman Fas Ligand/TNFSF6 ELISA Kit
CustomsNameHuman Fas Ligand/TNFSF6 ELISA Kit
ApplicationELISA
ReactivityHuman
Assay TypeSandwich ELISA
Suitable Sample Typeserum, plasma, cell culture supernates
Format96-well strip plate
Storage4℃ (unopened)standard stored at -20℃, others stored at 4℃ (opened)
Shipping Condition4℃
Sample Volume50 μl
Sensitivity3.42 pg/ml
Standard Curve Range15.63 - 1000 pg/ml
Spike Recovery Range87 % - 108 %
Mean Spike Recovery0.97
CV of Intra plate3.0 % - 4.2 %
CV of Inter plate3.9 % - 6.2 %
Components96-well polystyrene microplate coated with a monoclonal antibody against Fas Ligand
Human Fas Ligand Standard, lyophilized
Fas Ligand Detect Antibody
Standard Diluent
Streptavidin-HRP
Assay Buffer (10×)
Substrate (TMB)
Stop Solution
Washing Buffer (20×)
Plate Covers
DescribtionThis assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of human Fas Ligand. The Human Fas Ligand ELISA is for research use only. Not for diagnostic or therapeutic procedures.
Fas ligand (also known as TNFSF6, CD178, FasL or CD95L) is a type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Its binding with its receptor induces apoptosis. Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer. Fas ligand is a homotrimeric type II transmembrane protein expressed on cytotoxic T lymphocytes. It signals through trimerization of FasR, which spans the membrane of the "target" cell. This trimerization usually leads to apoptosis, or cell death. Soluble Fas ligand is generated by cleaving membrane-bound FasL at a conserved cleavage site by the external matrix metalloproteinase MMP-7. Apoptosis triggered by Fas-Fas ligand binding plays a fundamental role in the regulation of the immune system. Its functions include:T-cell homeostasis, cytotoxic T-cell activity, immune privilege, maternal tolerance, tumor counterattack.
Defective Fas-mediated apoptosis may lead to oncogenesis as well as drug resistance in existing tumors. Germline mutation of Fas is associated with autoimmune lymphoproliferative syndrome (ALPS), a childhood disorder of apoptosis.

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