|ProductName||Human IL-21 ELISA Kit|
|CustomsName||Human IL-21 ELISA Kit|
|Assay Type||Sandwich ELISA|
|Suitable Sample Type||serum, plasma, cell culture supernates|
|Format||96-well strip plate|
|Storage||4℃ (unopened) standard stored at -20℃, others stored at 4℃ (opened)|
|Sample Volume||50 μl|
|Standard Curve Range||62.50 - 4000 pg/ml|
|Spike Recovery Range||87 % - 112 %|
|Mean Spike Recovery||1.02|
|CV of Intra plate||4.5 % - 5.6 %|
|CV of Inter plate||7.2 % - 7.8 %|
|Components||96-well polystyrene microplate coated with a monoclonal antibody against IL-21|
Human IL-21 Standard, lyophilized
IL-21 Detect Antibody
Assay Buffer (10×)
washing Buffer (20×)
|Describtion||This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of human IL-21. The Human IL-21 ELISA is for research use only. Not for diagnostic or therapeutic procedures.|
Interleukin-21 (IL-21) is a cytokine that has potent regulatory effects on cells of the immune system, including natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells.This cytokine induces cell division/proliferation in its target cells. IL-21 is expressed in activated human CD4+ T cells but not in most other tissues.In addition, IL-21 expression is up-regulated in Th2 and Th17 subsets of T helper cells, as well as T follicular cells. Furthermore IL-21 is expressed in NK T cells regulating the function of these cells.
IL-21 has pathologic function in immune-inflammatory diseases. Data suggest the existence of a positive autocrine loop that could help to amplify and stabilize IL-21-driven, T cell-mediated responses. Moreover, it has antitumour activity and may have a role in the development of autoimmunity. IL-21 may have therapeutic potentials as an antitumor agent in the clinic.
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