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Human PDGFRB/CD140b ELISA Kit Plate

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Product Details

Standard - EK1232.jpg


BrandMultiSciences
CatNum70-EK1232
ProductNameHuman PDGFRB/CD140b ELISA Kit
CustomsNameHuman PDGFRB/CD140b ELISA Kit
ApplicationELISA
ReactivityHuman
Assay TypeSandwich ELISA
Suitable Sample Typeserum, plasma, cell culture supernates
Format96-well strip plate
Storage4℃ (unopened) standard stored at -20℃, others stored at 4℃ (opened)
Shipping Condition4℃
Sample Volume20 μl
Sensitivity48.54 pg/ml
Standard Curve Range625.00 - 40000 pg/ml
Spike Recovery Range70 % - 117 %
Mean Spike Recovery0.88
CV of Intra plate6.1 % - 8.7 %
CV of Inter plate7.0 % - 8.2 %
Components96-well polystyrene microplate coated with a monoclonal antibody against PDGFRB
Human PDGFRB Standard, lyophilized
PDGFRB Detect Antibody
Standard Diluent
Assay Buffer (10×)
Substrate (TMB)
Stop Solution
Washing Buffer (20×)
Plate Covers
DescribtionThis assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of human PDGFRB. The Human PDGFRB/CD140b ELISA is for research use only. Not for diagnostic or therapeutic procedures.
Platelet-derived growth factor receptor beta (PDGFRB), also known as CD140b, together with the structurally homolog protein PDGFRA (CD140a) are members of the class III subfamily of receptor tyrosine kinases (RTK) that also includes the receptors for M-CSF, SCF, and Flt-3 ligand. All class III RTKs are characterized by the presence of five immunoglobulin-like domains in their extracellular region and a kinase domain in their intracellular region.
PDGF is a major serum mitogen that can exist as a homo or hetero-dimeric protein consisting of disulfide-linked PDGF-A and PDGF-B chains. The PDGF-AA, PDGF‑BB, and PDGF‑AB isoforms have been shown to bind to PDGFRA and PDGFRB with different affinities. PDGFRA binds all three PDGF isoforms with high affinity, whereas PDGFRB binds PDGF-BB only with high-affinity. PDGF binding induces receptor homo-and hetero-dimerization and signal transduction. The expression of PDGFRA and PDGFRB are independently regulated in various cell types. Recombinant soluble PDGFRB binds PDGF with high affinity and is potent PDGF antagonist.


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