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Mouse IL-1β Pro-form ELISA Kit Plate

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Product Details

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ProductNameMouse IL-1β Pro-form ELISA Kit
CustomsNameMouse IL-1β Pro-form ELISA Kit
Assay TypeSandwich ELISA
Suitable Sample Typeserum, plasma, cell culture supernates
Format96-well strip plate
Storage4℃ (unopened) standard stored at -20℃, others stored at 4℃ (opened)
Shipping Condition4℃
Sample Volume20 μl
Sensitivity1.98 pg/ml
Standard Curve Range46.88 - 3000 pg/ml
Spike Recovery Range83 % - 111 %
Mean Spike Recovery0.97
CV of Intra plate1.9 % - 4.4 %
CV of Inter plate3.3 % - 4.1 %
Components96-well polystyrene microplate coated with a monoclonal antibody against IL-1β Pro-form
Mouse IL-1β Pro-form Standard, lyophilized
IL-1β Pro-form Detect Antibody
Standard Diluent
Assay Buffer (10×)
Substrate (TMB)
Stop Solution
Washing Buffer (20×)
Plate Covers
DescribtionThis assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of mouse IL-1β Pro-form. The Mouse IL-1β Pro-form ELISA is for research use only. Not for diagnostic or therapeutic procedures.
Interleukin-1 beta (IL-1β) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1β into the active 17 kDa protein requires the activation of inflammasomes. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1β. Although IL-1β is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions.
IL-1β signals through two receptors, IL-1RI and IL-1RII. These cytokines play important roles in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses. Their activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. Elevated levels of IL-1β have been associated with many chronic inflammatory conditions, giving IL-RA or IL-1β neutralizing antibodies potential therapeutical value.
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