|ProductName||Rat IL-1α ELISA Kit|
|CustomsName||Rat IL-1α ELISA Kit|
|Assay Type||Sandwich ELISA|
|Suitable Sample Type||serum, plasma, cell culture supernates|
|Format||96-well strip plate|
|Storage||4℃ (unopened) standard stored at -20℃, others stored at 4℃ (opened)|
|Sample Volume||20 μl|
|Standard Curve Range||7.81 - 500 pg/ml|
|Spike Recovery Range||72% -129 %|
|Mean Spike Recovery||1.03|
|CV of Intra plate||4.6% - 5.8 %|
|CV of Inter plate||1.7 % - 6.5 %|
|Components||96-well polystyrene microplate coated with a monoclonal antibody against IL-1α|
Rat IL-1α Standard, lyophilized
IL-1α Detect Antibody
Assay Buffer (10×)
washing Buffer (20×)
|Describtion||This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of rat IL-1α. The Rat IL-1α ELISA is for research use only. Not for diagnostic or therapeutic procedures.|
Interleukin-1 (IL-1) is an extracellular peptide of 17 kDa that designates two proteins, IL-1α and IL-1β. IL-1α is a pleiotropic cytokine that in humans is encoded by the IL1A gene. IL-1α is produced mainly by activated macrophages, as well as neutrophils, epithelial cells, and endothelial cells. It possesses metabolic, physiological, haematopoietic activities, and plays one of the central roles in the regulation of the immune responses.
IL-1α has been shown to interact with HAX1 and NDN, but the most clinically relevant is its synergism with TNF. IL-1α and TNF are both acute-phase cytokines that act to promote fever and inflammation.
IL-1α is currently being evaluated in clinical trials as a potential therapeutic in oncology indications. Blocking the activity of IL-1α has the potential to treat skin diseases such as acne.