Correlation of apolipoprotein A-I with T cell subsets and interferon-ү in coronary artery disease

  • Impact factors: 2.493
  • Publication: Immunity Inflammation and Disease
  • Author:Xinlin Xiong, Zonggang Duan, Haiyan Zhou, Guangwei Huang, Li Niu, Zhenhua Luo, Wei Li
  • DOI citation-doi:10.1002/iid3.797
  • Date:2023-03-14

Background The association of Apolipoprotein A-I (APOAI) with T cell subsets and interferon-ү (IFN-γ) in patients with coronary artery disease (CAD) has been not reported. Thus, this study aimed to investigate the association of APOAI with T cell subsets and IFN-γ in CAD. Methods This study included a total of 107 patients with CAD including acute coronary syndrome and chronic coronary syndrome. T cell subsets, and CD3-CD56+ natural killer cells were quantified by flow cytometric analysis. The serum concentrations of IFN-ү were measured by enzyme-linked immunosorbent assay. Lipid profiles, C-reactive protein (CRP), and fibrinogen were measured in the clinical laboratory. Clinical data was obtained duration hospitalization. Results The CD4+ T cells were higher in patients of the low-APOAI group (<median: 1.2 mmol/L) than in patients of the high-APOAI group(≥median: 1.2 mmol/L) ( p < .05). The CD8+ T cells were lower in patients of the low APOAI group than in patients of the high-APOAI group ( p < .05). APOAI was inversely associated with CD4+ T cells, IFN-γ, and was positively associated with CD8+ T cells ( p  .05). The high-density lipoprotein cholesterol (HDL-C) was also inversely associated with CD4+ T cells ( p < .05), and positively associated with CD8+ T cells ( p  .05). Conclusion The present study demonstrated the correlation of APOAI with T cell subsets and IFN-γ in CAD. These results provided novel information for the regulatory action between APOAI and T cell subsets and inflammatory immunity in CAD.

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