N6-methyladenosine modification in 18S rRNA promotes tumorigenesis and chemoresistance via HSF4b/HSP90B1/mutant p53 axis

  • Impact factors: 9.039
  • Publication: Cell Chemical Biology
  • Author:Binbin Chen, Ying Huang, Shuiqing He, Peng Yu, Lirong Wu, Hao Peng
  • DOI citation-doi:10.1016/j.chembiol.2023.01.006
  • Date:2023-02-16

Highlights

•m6A1832 facilitates the assembly of 80S ribosome via RPL24-18S rRNA bridge

•m6A1832 18S rRNA modification selectively regulates the translation of 5′TOP mRNAs

•METTL5 inhibits ubiquitin-dependent degradation of p53R280T via HSF4b/HSP90B1 axis

•METTL5 promotes tumorigenesis and chemoresistance via gain-of-function p53R280T

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