Tumor cell vaccine combined with Newcastle disease virus promote immunotherapy of lung cancer

  • Impact factors: 20.693
  • Publication: JOURNAL OF MEDICAL VIROLOGY
  • Author:Hui Wang, Fulong Nan, Zhou Zeng, Xueming Zhang, Dingxin Ke, Shuyun Zhang, Xiaoqiong Zhou, Delei Niu, Tianyu Fan, Shasha Jiang, Xianjuan Zhang, Bin Wang, Wanming Zhang
  • DOI citation-doi:10.1002/jmv.28554
  • Date:2023-02-04

Lung cancer is a fatal disease with the highest worldwide morbidity and mortality rates. Despite recent advances in targeted therapy and immune checkpoint inhibitors for cancer, their efficacy remained limited. Therefore, we designed a Newcastle disease virus (NDV)-modified tumor whole-cell vaccine as a therapeutic vaccine and identified its antigen presentation level to develop effective immunotherapy. Then, we calculated the therapeutic and immune-stimulating effects of NDV modified lung cancer cell vaccine and intratumoral NDV injection combination on tumor-bearing mice. The results showed that the immunogenic cell death (ICD) expression in NDV modified lung cancer cell vaccine stimulates dendritic cell maturation and T cell activation in vivo and in vitro . Moreover, NDV modified lung cancer cell vaccine combined with intratumoral NDV injection could significantly inhibit tumor growth and enhance the differentiation of Th1 cells and Inflammatory cell infiltration in vivo , leading to an excellent immunotherapeutic effect. Therefore, our results revealed that NDV modified lung cancer cell vaccine combined with intratumoral NDV injection could promote antigen presentation and induce a strong anti-tumor immune response, which provided a promising combined therapy strategy for tumor immunotherapy. This article is protected by copyright. All rights reserved.

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