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96 Wells Mouse IL-4 ELISA Kit

96 Wells Mouse IL-4 ELISA Kit


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Product Details

96 Wells Mouse IL-4 ELISA Kit

Brand MultiSciences
CatNum 70-EK204
Product Name Mouse IL-4 ELISA Kit
Customs Name Mouse IL-4 ELISA Kit
Application ELISA
Reactivity Mouse
Assay Type Sandwich ELISA
Suitable Sample Type serum, plasma, cell culture supernates
Format 96-well strip plate
Storage 4℃ (unopened) standard stored at -20℃, others stored at 4℃ (opened)
Shipping Condition 4℃
Sample Volume 20 μl
Sensitivity 0.34 pg/ml
Standard Curve Range 7.81 - 500 pg/ml
Spike Recovery Range 93 % - 106 %
Mean Spike Recovery 100%
CV of Intra plate 6.8 % - 8.3 %
CV of Inter plate 3.5 % - 6.6 %
Components 96-well polystyrene microplate coated with a monoclonal antibody against Mouse IL-4
Mouse IL-4 Standard, lyophilized
Mouse IL-4 Detect Antibody
Standard Diluent
Assay Buffer (10×)
Substrate (TMB)
Stop Solution
washing Buffer (20×)
Plate Covers
Describtion This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of mouse IL-4. The Mouse IL-4 ELISA is for research use only. Not for diagnostic or therapeutic procedures.

Interleukin 4 (IL-4) is an approximately 18-20 kDa monomeric cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Mouse IL-4 is synthesized as a 140 amino acid (aa) precursor with a 20 aa signal sequence and a 120 aa mature chain and mature mouse IL-4 shares 43%, and 63% aa sequence identity with human and rat IL-4.

IL-4 is a cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Upon activation by IL-4, Th2 cells subsequently produce additional IL-4 in a positive feedback loop. The cell that initially produces IL-4, thus inducing Th0 differentiation, has not been identified, but recent studies suggest that basophils may be the effector cell. It is closely related and has functions similar to IL-13.

IL-4 also has been shown to drive mitogenesis, dedifferentiation, and metastasis in rhabdomyosarcoma. IL-4, along with other Th2 cytokines, is involved in the airway inflammation observed in the lungs of patients with allergic asthma.