Glucagon Standard, lyophilized

Glucagon Detect Antibody

Standard Diluent

Streptavidin-HRP

Assay Buffer (10×)

Substrate (TMB)

Stop Solution

washing Buffer (20×)

Plate Covers

Glucagon is a 29-amino acid polypeptide, produced by alpha cells of the  pancreas. The polypeptide has a molecular weight of 3485 Da that plays a  critical role in glucose metabolism and homeostasis. It works to raise the  concentration of glucose in the bloodstream. It is also used as a medication  to treat a number of health conditions. Its effect is opposite to that of  insulin, which lowers the glucose. 

The pancreas releases glucagon when the concentration of glucose in the  bloodstream falls too low. Glucagon causes the liver to convert stored  glycogen into glucose, which is released into the bloodstream. High  blood-glucose levels, on the other hand, stimulate the release of insulin.  Glucagon allows glucose to be taken up and used by insulin-dependent tissues.  Thus, glucagon and insulin are part of a feedback system that keeps blood  glucose levels stable. Abnormally elevated levels of glucagon may be caused  by pancreatic tumors, such as glucagonoma, symptoms of which include  necrolytic migratory erythema, reduced amino acids, and hyperglycemia. It may  occur alone or in the context of multiple endocrine neoplasia type 1.