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Human Angiopoietin-2/ANG-2 Sandwich ELISA Kit

Human Angiopoietin-2/ANG-2 Sandwich ELISA Kit


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Human Angiopoietin-2/ANG-2 Sandwich ELISA Kit

Brand MultiSciences
CatNum 70-EK1215
Product Name Human Angiopoietin-2/ANG-2 ELISA Kit
Customs Name Human Angiopoietin-2/ANG-2 ELISA Kit
Application ELISA
Reactivity Human
Assay Type Sandwich ELISA
Suitable Sample Type serum, plasma, cell culture supernates
Format 96-well strip plate
Storage 4℃ (unopened) standard stored at -20℃, others stored at 4℃ (opened)
Shipping Condition 4℃
Sample Volume 20 μl
Sensitivity 2.61 pg/ml
Standard Curve Range 15.63 - 1000 pg/ml
Spike Recovery Range 79 % - 108 %
Mean Spike Recovery 0.92
CV of Intra plate 3.8 % - 4.1 %
CV of Inter plate 2.0 % - 3.0 %
Components 96-well polystyrene microplate coated with a monoclonal antibody against ANG-2
Human ANG-2 Standard, lyophilized
ANG-2 Detect Antibody
Standard Diluent
Assay Buffer (10×)
Substrate (TMB)
Stop Solution
Washing Buffer (20×)
Plate Covers
Describtion This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of human ANG-2. The Human Angiopoietin-2 / ANG-2 ELISA is for research use only. Not for diagnostic or therapeutic procedures.

Angiopoietin-2 (ANG-2) is an approximately 70 kDa secreted glycoprotein that plays a complex role in angiogenesis, inflammation, and vascular development. It is expressed in vascular endothelial and smooth muscle cells in highly angiogenic tissues, lung epithelial cells, differentiating myotubes, and neural progenitor cells. ANG-2 promotes endothelial cell survival, proliferation, and migration, and also promotes sprouting angiogenesis. It induces the loss of pericytes from vessel walls and an increase of vascular permeability. ANG-2 is required for the development of lymphatic vessels as well as the postnatal remodeling of both lymphatic and vascular vessels.

ANG-2 is elevated in patients with angiosarcoma. Research on ANG-2 has shown that it is involved in the onset of septic shock. Serum levels of ANG-2 expression are associated with the growth of multiple myeloma, angiogenesis, and overall survival in oral squamous cell carcinoma. Circulating ANG-2 is a marker for early cardiovascular disease in children on chronic dialysis. Kaposi's sarcoma-associated herpesvirus induces rapid release of ANG-2 from endothelial cells.