96-well polystyrene microplate (12 strips of 8 wells) coated with a monoclonal antibody against human Betacellulin

Human Betacellulin Standard, lyophilized

Betacellulin Detect Antibody

Standard Diluent

Streptavidin-HRP

Assay Buffer (10×)

Substrate (TMB)

Stop Solution

Washing Buffer (20×)

Adhesive Films 

This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of human β-NGF. The Human  β-NGF ELISA is for research use only. Not for diagnostic or therapeutic procedures.                  Betacellulin, also known as BTC is a protein that in humans is encoded by the BTC gene. This gene is mapped to 4q13.3. The protein encoded by this gene is a member of the EGF family of growth factors. It is synthesized primarily as a transmembrane precursor, which is then processed to mature molecule by proteolytic events. This protein is a ligand for the EGF receptor. It is the growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. This protein is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.

Some data show that BTC exerts potent angiogenic activity through activation of EGF receptors, mitogen-activated protein kinase, and PtdIns 3'-kinase/Akt in endothelial cells.