96-well polystyrene microplate coated with a monoclonal antibody against C-peptide

Human C-peptide Standard, lyophilized

C-peptide Detect Antibody

Standard Diluent

Streptavidin-HRP

Assay Buffer (10×)

Substrate (TMB)

Stop Solution

Washing Buffer (20×)

Plate Covers

C-Peptide, or connective peptide, is secreted by Pancreatic beta cell. It shares a common proinsulin with the mature Insulin. It is a short 31-amino-acid polypeptide that connects insulin's A-chain to its B-chain in the proinsulin molecule. C-peptide has been shown to bind to the surface of a number of cell types such as neuronal, endothelial, fibroblast and renal tubular, at nanomolar concentrations to a receptor that is likely G-protein-coupled. 

C-peptide exerts vascular anti-inflammatory effects via the downregulation of endothelial cell surface adhesion molecules, the reduction of inflammatory cytokine production, and the protection of vascular smooth muscle cells from detrimental Insulin effects. C-peptide administration in animals that had C-peptide deficiency (type 1 model) with nephropathy improves renal function and structure; it decreases urinary albumin excretion and prevents or decreases diabetes-induced glomerular changes secondary to mesangial matrix expansion.