MULTI SCIENCES
Human CTLA-4/CD152 ELISA Kit Distributor
Human CTLA-4/CD152 ELISA Kit Distributor
SKU:EK1241
Product Details
| Brand | MultiSciences |
|---|---|
| CatNum | 70-EK1241 |
| Product Name | Human CTLA-4/CD152 ELISA Kit |
| Customs Name | Human CTLA-4/CD152 ELISA Kit |
| Application | ELISA |
| Reactivity | Human |
| Assay Type | Sandwich ELISA |
| Suitable Sample Type | serum, plasma, cell culture supernates |
| Format | 96-well strip plate |
| Storage | 4℃ (unopened) standard stored at -20℃, others stored at 4℃ (opened) |
| Shipping Condition | 4℃ |
| Sample Volume | 50 μl |
| Sensitivity | 0.71 pg/ml |
| Standard Curve Range | 93.75 - 6000 pg/ml |
| Spike Recovery Range | 78 % - 120 % |
| Mean Spike Recovery | 0.94 |
| CV of Intra plate | 2.4 % - 3.7 % |
| CV of Inter plate | 3.1 % - 4.3 % |
| Components | 96-well polystyrene microplate coated with a monoclonal antibody against CTLA-4 Human CTLA-4 Standard, lyophilized CTLA-4 Detect Antibody Standard Diluent Assay Buffer (10×) Substrate (TMB) Stop Solution Washing Buffer (20×) Plate Covers |
| Describtion | This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of human CTLA-4. The Human CTLA-4/CD152 ELISA is for research use only. Not for diagnostic or therapeutic procedures. Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), also known as CD152, is a member of the immunoglobulin superfamily that is expressed on the surface of helper T cells. CTLA-4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86. CTLA-4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. CTLA-4 functions as an immune checkpoint, downregulates the immune system, acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells. Intracellular CTLA-4 is also found in regulatory T cells and may be important to their function. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves' disease, Hashimoto's thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, primary biliary cirrhosis and other autoimmune diseases. Polymorphisms of the CTLA-4 gene are associated with autoimmune diseases such as autoimmune thyroid disease and multiple sclerosis, though this association is often weak. In systemic lupus erythematosus, the splice variant sCTLA-4 is found to be aberrantly produced and found in the serum of patients with active systemic lupus erythematosus. |
