|Product Name||Human FGF-19 ELISA Kit|
|Customs Name||Human FGF-19 ELISA Kit|
|Assay Type||Sandwich ELISA|
|Suitable Sample Type||serum, plasma, cell culture supernates|
|Format||96-well strip plate|
|Storage||4℃ (unopened) standard stored at -20℃, others stored at 4℃ (opened)|
|Sample Volume||50 μl|
|Standard Curve Range||15.63 - 1000 pg/ml|
|Spike Recovery Range||85 % - 114 %|
|Mean Spike Recovery||0.99|
|CV of Intra plate||2.8 % - 4.6 %|
|CV of Inter plate||2.5 % - 4.8 %|
|Components||96-well polystyrene microplate coated with a monoclonal antibody against FGF-19
Human FGF-19 Standard, lyophilized
FGF-19 Detect Antibody
Assay Buffer (10×)
Washing Buffer (20×)
|Describtion||This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of human FGF-19. The Human FGF-19 ELISA is for research use only. Not for diagnostic or therapeutic procedures.
Fibroblast growth factor 19 (FGF-19) is a protein that in humans is encoded by the FGF19 gene. FGF-19 regulates new bile acid synthesis, acting through the FGFR4/Klotho-β receptor complexes in the liver to inhibit CYP7A1. FGF-19 also has metabolic effects, affecting glucose and lipid metabolism when used in experimental mouse models.
Patients with chronic diarrhea due to bile acid malabsorption have been shown to have reduced fasting FGF-19. FGF-19 is also found in the liver of patients with cholestasis. Patients with the metabolic syndrome, non-alcoholic fatty liver disease and insulin resistance have reduced levels of FGF-19. FGF-19 increases to normal values in obese patients who undergo Roux-en-Y gastric bypass bariatric surgery.