MultiSciences

70-EK120

Human IL-20 ELISA Kit

Human IL-20 ELISA Kit

ELISA

Human

Sandwich ELISA

serum, plasma, cell culture supernates

96-well strip plate

4℃ (unopened)standard stored at -20℃, others stored at 4℃ (opened)

4℃

50 μl

11.87 pg/ml

46.88 - 3000 pg/ml

78 % - 121 %

0.96

2.9 % - 4.2 %

2.8 % - 4.7 %

96-well polystyrene microplate coated with a monoclonal antibody against IL-20
Human IL-20 Standard, lyophilized
IL-20 Detect Antibody
Standard Diluent
Streptavidin-HRP
Assay Buffer (10×)
Substrate (TMB)
Stop Solution
washing Buffer (20×)
Plate Covers

This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of human IL-20. The Human IL-20 ELISA is for research use only. Not for diagnostic or therapeutic procedures.
Human interleukin 20 (IL-20) is a protein belonging to the IL-10 family of cytokines. It exhibits approximately 28% amino acid (aa) identity with IL-10 and 76% aa identity with mouse IL-20. IL-20 is produced by activated keratinocytes and monocytes and transmits an intracellular signal through two distinct cell-surface receptor complexes on keratinocytes and other epithelial cells. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. In addition, IL-20 regulates proliferation and differentiation of keratinocytes during inflammation, particularly inflammation associated with the skin. IL-20 also causes cell expansion of multipotential hematopoietic progenitor cells. The over-expression of both human and mouse forms of IL-20 results in keratinocyte hyperproliferation, abnormal epidermal differentiation, and neonatal lethality.