MultiSciences

70-EK1134

Human osteoprotegerin/OPG ELISA Kit

Human osteoprotegerin/OPG ELISA Kit

ELISA

Human

Sandwich ELISA

serum, plasma, cell culture supernates

96-well strip plate

4℃ (unopened) standard stored at -20℃, others stored at 4℃ (opened)

4℃

10 μl

1.36 pg/ml

62.50 - 4000 pg/ml

94 % - 114 %

1.03

4.2 % - 5.7 %

6.4 % - 7.5 %

96-well polystyrene microplate coated with a monoclonal antibody against OPG

Human OPG Standard, lyophilized

OPG Detect Antibody

Standard Diluent

Streptavidin-HRP

Assay Buffer (10×)

Substrate (TMB)

Stop Solution

Washing Buffer (20×)

Plate Covers

This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of human OPG. The Human osteoprotegerin/OPG ELISA is for research use only. Not for diagnostic or therapeutic procedures.

Osteoprotegerin (OPG), also known as OCIF or TNFRSF11B, is a cytokine receptor, and a member of the tumor necrosis factor (TNF) receptor superfamily. OPG can reduce the production of osteoclasts by inhibiting the differentiation of osteoclast precursors into osteoclasts and also regulates the resorption of osteoclasts in vitro and in vivo. Recombinant human OPG specifically acts on bone, increasing bone mineral density and bone volume.

Elevated OPG levels has been reported in heart diseases, in placebo effect serum responses in IBS patients and in severe mental disorders. In recent years, it has been hypothesized that OPG may be a link between bone and cardiovascular disease. It has been particularly related to the increase in cardiovascular risk in patients suffering from diabetes.