|Product Name||Human Proprotein Convertase 9/PCSK9 ELISA Kit|
|Customs Name||Human Proprotein Convertase 9/PCSK9 ELISA Kit|
|Assay Type||Sandwich ELISA|
|Suitable Sample Type||serum, plasma, cell culture supernates|
|Format||96-well strip plate|
|Storage||4℃ (unopened) standard stored at -20℃, others stored at 4℃ (opened)|
|Sample Volume||10 μl (prediluted)|
|Standard Curve Range||62.50 - 4000 pg/ml|
|CV of Intra plate||1.7 % - 7.6 %|
|CV of Inter plate||2.4 % - 5.8 %|
|Components||96-well polystyrene microplate coated with a monoclonal antibody against PCSK9
Human PCSK9 Standard, lyophilized
PCSK9 Detect Antibody
Assay Buffer (10×)
Washing Buffer (20×)
|Describtion||This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of human PCSK9. The Human Proprotein Convertase 9/PCSK9 is for research use only. Not for diagnostic or therapeutic procedures.
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme belonging to the proteinase K subfamily of the secretory subtilase family. It is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. PCSK9 binds to the receptor for low-density lipoprotein (LDL) cholesterol, inducing LDLR degradation.
Variants of PCSK9 can reduce or increase circulating cholesterol. Other variants are associated with a rare autosomal dominant familial hypercholesterolemia (HCHOLA3). The mutations increase its protease activity, reducing LDLR levels and preventing the uptake of cholesterol into the cells.