MultiSciences

70-EK1163

Human ST2/IL-1R4 ELISA Kit

Human ST2/IL-1R4 ELISA Kit

ELISA

Human

Sandwich ELISA

serum, plasma, cell culture supernates

96-well strip plate

4℃ (unopened)standard stored at -20℃, others stored at 4℃ (opened)

4℃

100 μl

1.10 pg/ml

31.25 - 2000 pg/ml

92 % - 122 %

1.07

4.2 % - 4.9 %

4.0 % - 6. 0 %

96-well polystyrene microplate coated with a monoclonal antibody against ST2
Human ST2 Standard, lyophilized
ST2 Detect Antibody
Standard Diluent
Streptavidin-HRP
Assay Buffer (10×)
Substrate (TMB)
Stop Solution
Washing Buffer (20×)
Plate Covers

This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of human ST2. The Human ST2/IL-1 R4 ELISA is for research use only. Not for diagnostic or therapeutic procedures.
Suppression of Tumorigenicity 2 (ST2), also known as IL-1 R4, is an Interleukin-1 receptor family glycoprotein that contributes to Th2 immune responses. ST2 is expressed on the surface of mast cells, activated Th2 cells, macrophages, and cardiac myocytes. ST2 binds IL-33, a pro-inflammatory IL-1 family cytokine with intracellular and extracellular activities. In addition to its role in promoting mast cell and Th2 dependent inflammation, transmembrane ST2 activation enhances inflammation-associated hypernociception and protects from atherosclerosis and cardiac myocyte hypertrophy. The soluble ST2 isoform is elevated in the serum under inflammatory conditions including allergic asthma, sepsis, trauma, dengue fever, and pulmonary disease. Serum ST2 elevation is also associated with multiple aspects of heart failure including aortic stenosis, congestive cardiomyopathy, and risk of cardiovascular heart failure and death.