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Human UPAR Enzyme Immunoassay Kit

Human UPAR Enzyme Immunoassay Kit


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Product Details

Human UPAR  Enzyme Immunoassay Kit

Brand MultiSciences
CatNum 70-EK1171
Product Name Human uPAR ELISA Kit
Customs Name Human uPAR ELISA Kit
Application ELISA
Reactivity Human
Assay Type Sandwich ELISA
Suitable Sample Type serum, plasma, cell culture supernates
Format 96-well strip plate
Storage 4℃ (unopened) standard stored at -20℃, others stored at 4℃ (opened)
Shipping Condition 4℃
Sample Volume 10 μl
Sensitivity 0.87 pg/ml
Standard Curve Range 62.50 - 4000 pg/ml
Spike Recovery Range 87 % - 114%
Mean Spike Recovery 1.01
CV of Intra plate 3.0 % - 4.7 %
CV of Inter plate 2.1 % - 5.0 %
Components 96-well polystyrene microplate coated with a monoclonal antibody against uPAR
Human uPAR Standard, lyophilized
uPAR Detect Antibody
Standard Diluent
Assay Buffer (10×)
Substrate (TMB)
Stop Solution
Washing Buffer (20×)
Plate Covers
Describtion This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of human uPAR. The Human uPAR ELISA is for research use only. Not for diagnostic or therapeutic procedures.
Urokinase-type Plasminogen Activator Receptor (uPAR) is a cell surface receptor that binds urokinase-type plasminogen activator (uPA) with high affinity, thereby facilitating the pericellular activation of plasminogen. It is multidomain glycoprotein tethered to the cell membrane with a glycosylphosphotidylinositol (GPI) anchor. uPAR was originally identified as a saturable binding site for urokinase on the cell surface.
uPAR binds urokinase and thus restricts plasminogen activation to the immediate vicinity of the cell membrane. Besides the primary ligand urokinase, uPAR interacts with several other proteins, among others: vitronectin, the uPAR associated protein and the integrin family of membrane proteins.
uPAR is a part of the plasminogen activation system, which in the healthy body is involved in tissue reorganization events such as mammary gland involution and wound healing. uPAR has been involved in various other processes related to cancer, such as cell migration, cell cycle regulation, and cell adhesion.