MultiSciences

EK1154

Human VEGF-C ELISA Kit

Human VEGF-C ELISA Kit

96T

ELISA

Human

SDS - EK1154

Sandwich ELISA

serum, plasma, cell culture supernates

96-well strip plate

4℃ (unopened)standard stored at -20℃, others stored at 4℃ (opened)

4℃

100 μl (prediluted)

4.24 pg/ml

31.25 - 2000 pg/ml

80%-119%

96%

3.6 % - 7.0 %

3.3 % - 6.5%

96-well polystyrene microplate coated with a monoclonal antibody against VEGF-C
Human VEGF-C Standard, lyophilized
VEGF-C Detect Antibody
Standard Diluent
Streptavidin-HRP
Assay Buffer (10×)
Substrate (TMB)
Stop Solution
Washing Buffer (20×)
Plate Covers

This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of human VEGF-C. The Human VEGF-C ELISA is for research use only. Not for diagnostic or therapeutic procedures.
Vascular endothelial growth factor C (VEGF-C) is a dimeric, secreted protein that is a member of PDGF/VEGF family. After translation, VEGF-C consists of three domains: the central VEGF homology domain (VHD), the N-terminal domain (propeptide) and a C-terminal domain (propeptide). The main function of VEGF-C is in lymphangiogenesis, where it acts on lymphatic endothelial cells (LECs) primarily via its receptor VEGFR-3 promoting survival, growth and migration. It was shown to be a specific growth factor for lymphatic vessels in a variety of models. However, in addition to its effect on lymphatic vessels, it can also promote the growth of blood vessels and regulate their permeability. The effect on blood vessels can be mediated via its primary receptor VEGFR-3 or its secondary receptor VEGFR-2. Apart from vascular targets, VEGF-C is also important for neural development and blood pressure regulation.
While a lack of VEGF-C results in lymphedema, too much VEGF-C is implicated in tumor angiogenesis and metastasis.