MULTI SCIENCES
Mouse Endoglin/CD105 ELISA Assay Kit
Mouse Endoglin/CD105 ELISA Assay Kit
SKU:EK2149
Product Details
| Brand | MultiSciences |
|---|---|
| CatNum | 70-EK2149 |
| Product Name | Mouse Endoglin/CD105 ELISA Kit |
| Customs Name | Mouse Endoglin/CD105 ELISA Kit |
| Application | ELISA |
| Reactivity | Mouse |
| Assay Type | Sandwich ELISA |
| Suitable Sample Type | serum, plasma, cell culture supernates |
| Format | 96-well strip plate |
| Storage | 4℃ (unopened) standard stored at -20℃, others stored at 4℃ (opened) |
| Shipping Condition | 4℃ |
| Sample Volume | 20 μl |
| Sensitivity | 3.36 pg/ml |
| Standard Curve Range | 156.25 - 10000 pg/ml |
| Spike Recovery Range | 83 % - 117 % |
| Mean Spike Recovery | 0.99 |
| CV of Intra plate | 2.0 % - 5.3 % |
| CV of Inter plate | 4.1 % - 6.0 % |
| Components | 96-well polystyrene microplate coated with a monoclonal antibody against TGF-β1 Mouse TGF-β1 Standard, lyophilized TGF-β1 Detect Antibody Streptavidin-HRP Assay Buffer (10×) Substrate (TMB) Stop Solution washing Buffer (20×) HCl NaOH Plate Covers |
| Describtion | This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of mouse Endoglin. The Mouse Endoglin/CD105 ELISA is for research use only. Not for diagnostic or therapeutic procedures. Endoglin also known as CD105 is a type I membrane glycoprotein located on cell surfaces and is part of the TGF-β receptor complex. It is involved in modulating a response to the binding of TGF-β1, TGF-β3, activin-A, BMP-2 and BMP-7. It has been postulated that Endoglin is involved in the cytoskeletal organization affecting cell morphology and migration. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development. Experimental mice without the Endoglin gene die due to cardiovascular abnormalities. In humans, Endoglin may be involved in the autosomal dominant disorder known as hereditary hemorrhagic telangiectasia (HHT) type 1. This condition leads to frequent nose bleeds, telangiectases on skin and mucosa and may cause arteriovenous malformations in different organs including brain, lung, and liver. |
