MULTI SCIENCES
Mouse TRANCE/TNFSF11/RANKL Antibody ELISA Kit
Mouse TRANCE/TNFSF11/RANKL Antibody ELISA Kit
SKU:EK2208
Product Details
| Brand | MultiSciences |
|---|---|
| CatNum | 70-EK2208 |
| Product Name | Mouse TRANCE/TNFSF11/RANKL ELISA Kit |
| Customs Name | Mouse TRANCE/TNFSF11/RANKL ELISA Kit |
| Application | ELISA |
| Reactivity | Mouse |
| Assay Type | Sandwich ELISA |
| Suitable Sample Type | serum, plasma, cell culture supernates |
| Format | 96-well strip plate |
| Storage | 4℃ (unopened) standard stored at -20℃, others stored at 4℃ (opened) |
| Shipping Condition | 4℃ |
| Sample Volume | 20 μl |
| Sensitivity | 0.74 pg/ml |
| Standard Curve Range | 31.25 - 2000 pg/ml |
| Spike Recovery Range | 85 % - 118 % |
| Mean Spike Recovery | 0.94 |
| CV of Intra plate | 2.9 % - 7.9 % |
| CV of Inter plate | 3.1 % - 5.4 % |
| Components | 96-well polystyrene microplate coated with a monoclonal antibody against IL-22 Mouse IL-22 Standard, lyophilized IL-22 Detect Antibody Standard Diluent Streptavidin-HRP Assay Buffer (10×) Substrate (TMB) Stop Solution washing Buffer (20×) Plate Covers |
| Describtion | This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of mouse TRANCE. The Mouse TRANCE/TNFSF11/RANKL ELISA is for research use only. Not for diagnostic or therapeutic procedures. TNF-related activation-induced cytokine (TRANCE), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), receptor activator of nuclear factor kappa-B ligand (RANKL), is a member of the TNF superfamily. Cells known to express TRANCE include osteoblasts, CD4+ and CD8+ T cells, megakaryocytes, bronchial and intestinal epithelium and so on. TRANCE appears to play a central role in both immune response and bone morphogenesis. During bone development and remodeling, TRANCE expression by osteoblasts in conjunction with M-CSF induces osteoclast formation and activation, resulting in bone resorption. This allows for subsequent bone deposition and remodeling. TRANCE also plays a role in pathological osteoporosis. Its inappropriate expression by activated lymphocytes and osteoblasts results in excessive joint and bone resorption vs. deposition. Overproduction of TRANCE is implicated in a variety of degenerative bone diseases, such as rheumatoid arthritis and psoriatic arthritis. |
