|Product Name||Rat IL-17A ELISA Kit|
|Customs Name||Rat IL-17A ELISA Kit|
|Assay Type||Sandwich ELISA|
|Suitable Sample Type||serum, plasma, cell culture supernates|
|Format||96-well strip plate|
|Storage||4℃ (unopened) standard stored at -20℃, others stored at 4℃ (opened)|
|Sample Volume||10 μl|
|Standard Curve Range||3.13 - 200 pg/ml|
|Spike Recovery Range||94 % - 119 %|
|Mean Spike Recovery||1.03|
|CV of Intra plate||3.9 % - 7.1 %|
|CV of Inter plate||3.0 % - 3.9 %|
|Components||96-well polystyrene microplate coated with a monoclonal antibody against IL-17A
Rat IL-17A Standard, lyophilized
IL-17A Detect Antibody
Assay Buffer (10×)
Washing Buffer (20×)
|Describtion||This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of rat IL-17A. The Rat IL-17A ELISA is for research use only. Not for use in therapeutic procedures.
IL-17, also known as IL-17A and CTLA-8, is a homodimeric cytokine of about 32 kDa. IL-17 is a cytokine that acts as a potent mediator in delayed-type reactions by increasing chemokine production in various tissues to recruit monocytes and neutrophils to the site of inflammation, similar to IFN-γ. IL-17 is produced by T-helper cells and is induced by IL-23 which results in destructive tissue damage in delayed-type reactions. IL-17 as a family functions as a proinflammatory cytokine that responds to the invasion of the immune system by extracellular pathogens and induces destruction of the pathogen's cellular matrix. IL-17 acts synergistically with TNF and IL-1.
IL-17 family has been linked to many immune / autoimmune related diseases including rheumatoid arthritis, asthma, lupus, allograft rejection, anti-tumour immunity and recently Psoriasis.Increased levels of IL-17 have been associated with several conditions, including airway inflammation, rheumatoid arthritis, intraperitoneal abscesses and adhesions, inflammatory bowel disease, allograft rejection, psoriasis, cancer and multiple sclerosis.