Endoglin, also known as CD105, is a type I transmembrane glycoprotein located on the surface of cell membranes, known as TGF- β One of the receptor complexes. It participates in regulation and TGF- β 1. TGF- β 3. Response to Activin-A, BMP-2, and BMP-7 binding. Endoglin is speculated to be involved in the formation of the cytoskeleton that affects cell morphology and migration. It plays a role in the development of the cardiovascular system and vascular remodeling. During the development of the heart, the expression of Endoglin is regulated. Experimental mice lacking the Endoglin gene died due to cardiovascular abnormalities. In humans, Endoglin may be involved in autosomal dominant diseases, known as type 1 hereditary hemorrhagic telangiectasia (HHT). It can cause frequent epistaxis, skin and mucosal capillary dilation, and cause arteriovenous malformations in different organs such as the brain, lungs, and liver.

• Molecular name: ENG, endoglin
• Gene family: CD molecules
• Alias: END; HHT1; CD105
• Former name: ORW1; ORW
• Full name: Osler Rendu Weber syntax 1