HGNC ID: 3336
Target Abstract:
F4/80 is a transmembrane protein that, although also expressed on Kupffer cells and Langerhans cells, can still serve as a marker for macrophages. After being stimulated by macrophage colony stimulating factor in vitro, bone marrow cells upregulate the expression of F4/80 antigen. Inducing peripheral tolerance mediated by CD8+T cells also requires the involvement of F4/80.
ADGRE1 Target Infomation Overview
- Target Symbol: ADGRE1, adhesion G protein-coupled receptor E1
- Gene Groups: Adhesion G protein-coupled receptors, subfamily E
- Previous Names: TM7LN3; EMR1
- Alias Names: egf-like module containing, mucin-like, hormone receptor-like sequence 1; egf-like module containing, mucin-like, hormone receptor-like 1
ADGRE1, adhesion G protein-coupled receptor E1 Target Infomation by Species
- Human
- Mouse
- Rat
Human ADGRE1 Target Information
- Target Symbol: ADGRE1, adhesion G protein-coupled receptor E1
- Alias:
- egf-like module containing, mucin-like, hormone receptor-like 1
- egf-like module containing, mucin-like, hormone receptor-like sequence 1
- EGF-like module receptor 1
- EGF-like module-containing mucin-like hormone receptor-like 1
- EMR1
- EMR1 hormone receptor
- TM7LN3
- NCBI_Gene: 2015
- UniProtKB: Q14246
Human ADGRE1 Predicted Functions
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in external side of plasma membrane. Predicted to be integral component of plasma membrane.
Mouse Adgre1 Target Information
- Target Symbol: Adgre1, adhesion G protein-coupled receptor E1
- Alias:
- DD7A5-7
- EGF-like module containing, mucin-like, hormone receptor-like sequence 1
- EGF-TM7
- Emr1
- F4/80
- glycoprotein f4/80 protein
- Gpf480
- Ly71
- lymphocyte antigen 71
- TM7LN3
- NCBI_Gene: 13733
Mouse Adgre1 Predicted Functions
Enables epidermal growth factor binding activity and epidermal growth factor-activated receptor activity. Involved in cellular response to amino acid stimulus and positive regulation of fibroblast proliferation. Acts upstream of or within several processes, including animal organ development; epidermal growth factor receptor signaling pathway; and protein autophosphorylation. Located in several cellular components, including basolateral plasma membrane; endocytic vesicle; and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; brain; integumental system; limb; and respiratory system. Used to study Coronavirus infectious disease and aortic valve disease. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; lung non-small cell carcinoma (multiple); pancreatic cancer; prostate cancer; and pulmonary tuberculosis. Orthologous to human EGFR (epidermal growth factor receptor).
Rat Adgre1 Target Information
- Target Symbol: Adgre1, adhesion G protein-coupled receptor E1
- Alias:
- adhesion G protein-coupled receptor E2
- cell surface glycoprotein EMR1
- EGF-like module containing, mucin-like, hormone receptor-like 1
- EGF-like module containing, mucin-like, hormone receptor-like sequence 1
- EGF-like module receptor 1
- EGF-like module-containing mucin-like hormone receptor-like 1
- Emr1
- EMR1 hormone receptor
- NCBI_Gene: 316137
- UniProtKB: Q5Y4N8
Rat Adgre1 Predicted Functions
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in external side of plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human ADGRE1 (adhesion G protein-coupled receptor E1).