HGNC ID: 1667
Target Abstract:
CD38 is a membrane-bound glycoprotein that catalyzes the synthesis and degradation of cyclic ADP-ribose. It is involved in cell adhesion and signal transduction. CD31 is the ligand for CD38, and their binding can induce apoptosis in bone marrow B cells but prevent apoptosis in tonsil B cells and promote proliferation of splenic B cells. CD38 is normally expressed in thymocytes, early B and T cells, germinal center B cells, and some T cells. However, it is aberrantly expressed in multiple myeloma cells, primary effusion lymphoma, and some chronic lymphocytic leukemia.
CD38 Target Infomation Overview
- Target Symbol: CD38, CD38 molecule
- Gene Groups: CD molecules
- Alias Names: ADP-ribosyl cyclase 1; NAD(+) nucleosidase; CD38 antigen (p45)
CD38, CD38 molecule Target Infomation by Species
- Human
- Mouse
- Rat
Human CD38 Target Information
- Target Symbol: CD38, CD38 molecule
- Alias:
- 2′-phospho-ADP-ribosyl cyclase
- 2′-phospho-ADP-ribosyl cyclase/2′-phospho-cyclic-ADP-ribose transferase
- 2′-phospho-cyclic-ADP-ribose transferase
- ADP-ribosyl cyclase 1
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
- ADPRC 1
- ADPRC1
- cADPr hydrolase 1
- cd38 antigen
- CD38 antigen (p45)
- cluster of differentiation 38
- cyclic ADP-ribose hydrolase 1
- ecto-nicotinamide adenine dinucleotide glycohydrolase
- NAD(+) nucleosidase
- T10
- NCBI_Gene: 952
- UniProtKB: P28907
Human CD38 Predicted Functions
Predicted to enable NAD+ nucleosidase activity and phosphorus-oxygen lyase activity. Involved in several processes, including B cell receptor signaling pathway; positive regulation of B cell proliferation; and regulation of transcription, DNA-templated. Located in plasma membrane. Implicated in type 1 diabetes mellitus and type 2 diabetes mellitus.
Mouse Cd38 Target Information
- Target Symbol: Cd38, CD38 antigen
- Alias:
- CD38 antigen, related sequence 1
- Cd38-rs1
- NCBI_Gene: 12494
Mouse Cd38 Predicted Functions
Enables hydrolase activity, acting on glycosyl bonds; identical protein binding activity; and phosphorus-oxygen lyase activity. Acts upstream of or within positive regulation of B cell proliferation. Located in cell surface and membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human CD38 (CD38 molecule).
Rat Cd38 Target Information
- Target Symbol: Cd38, CD38 molecule
- Alias:
- 2′-phospho-ADP-ribosyl cyclase
- 2′-phospho-ADP-ribosyl cyclase/2′-phospho-cyclic-ADP-ribose transferase
- 2′-phospho-cyclic-ADP-ribose transferase
- ADP-ribosyl cyclase 1
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
- ADPRC 1
- cADPr hydrolase 1
- CD38 antigen
- CD38 antigen (ADP-ribosyl cyclase / cyclic ADP-ribose hydrolase)
- CD38H
- cyclic ADP-ribose hydrolase 1
- NCBI_Gene: 25668
- UniProtKB: Q64244
Rat Cd38 Predicted Functions
Enables NAD+ nucleosidase activity. Involved in several processes, including blood vessel diameter maintenance; long-term synaptic depression; and negative regulation of bone resorption. Located in basolateral plasma membrane; nucleus; and secretory granule membrane. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human CD38 (CD38 molecule).