HGNC ID: 4604
Target Abstract:
CXCL1, CXCL2 and CXCL3, known as GRO alpha, GRO beta (MIP-2 alpha) and GRO gamma (MIP-2 beta), respectively, are members of the CXC subfamily of chemokines. The mature CXCL1/2/3 proteins bind with high affinity to the B-type IL-8 receptor and are potent neutrophil attractants and activators. Chemokines act primarily on leukocytes to regulate their transport. In general, chemokine α family members preferentially chemotaxis and activate neutrophils. Recombinant human growth-regulated oncogene γ (GRO-γ) is a 7.9 kDa protein consisting of 73 amino acids, including the “ELR” motif common to the CXC chemokine family that binds to CXCR1 or CXCR2. Mature human CXCL3 (aa 35-107) shares 70% and 74% amino acid sequence homology with mouse and rat CXCL3, respectively.CXCL3 plays a key role in monocyte migration and adhesion through its interaction with the CXCR2 receptor.
CXCL3 Target Infomation Overview
- Target Symbol: CXCL3, C-X-C motif chemokine ligand 3
- Gene Groups: Chemokine ligands
- Alias: SCYB3; GROg; MIP-2b; CINC-2b
- Previous Names: GRO3
- Alias Names: GRO3 oncogene; chemokine (C-X-C motif) ligand 3
CXCL3, C-X-C motif chemokine ligand 3 Target Infomation by Species
- Human
- Mouse
- Rat
Human CXCL3 Target Information
- Target Symbol: CXCL3, C-X-C motif chemokine ligand 3
- Alias:
- C-X-C motif chemokine 3
- chemokine (C-X-C motif) ligand 3
- CINC-2b
- GRO-gamma
- GRO-gamma(1-73)
- GRO3
- GRO3 oncogene
- GROg
- growth-regulated protein gamma
- macrophage inflammatory protein 2-beta
- melanoma growth stimulatory activity gamma
- MGSA gamma
- MIP-2b
- MIP2-beta
- MIP2B
- SCYB3
- NCBI_Gene: 2921
- UniProtKB: P19876
Human CXCL3 Predicted Functions
Predicted to enable CXCR chemokine receptor binding activity and chemokine activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide and killing of cells of other organism. Located in extracellular space.
Mouse Cxcl3 Target Information
- Target Symbol: Cxcl3, chemokine (C-X-C motif) ligand 3
- Alias:
- Dcip1
- gene model 1960, (NCBI)
- Gm1960
- NCBI_Gene: 330122
Mouse Cxcl3 Predicted Functions
Enables chemokine activity. Involved in neutrophil chemotaxis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in genitourinary system; gut; and thymus. Orthologous to human CXCL1 (C-X-C motif chemokine ligand 1); CXCL2 (C-X-C motif chemokine ligand 2); and CXCL3 (C-X-C motif chemokine ligand 3).
Rat Cxcl3 Target Information
- Target Symbol: Cxcl3, C-X-C motif chemokine ligand 3
- Alias:
- C-X-C motif chemokine 3
- chemokine (C-X-C motif) ligand 3
- Cinc-2
- Cinc2
- cytokine-induced neutrophil chemoattractant 2
- cytokine-induced neutrophil chemoattractant-2
- gene model 1960, (NCBI)
- Gm1960
- macrophage inflammatory protein 2-alpha/beta
- MIP2-alpha/beta
- NCBI_Gene: 171551
- UniProtKB: Q10746
Rat Cxcl3 Predicted Functions
Enables chemokine activity. Involved in several processes, including cellular response to lipopolysaccharide; neutrophil chemotaxis; and positive regulation of cytosolic calcium ion concentration. Located in extracellular space. Biomarker of Coronavirus infectious disease and bacterial pneumonia. Orthologous to human CXCL1 (C-X-C motif chemokine ligand 1); CXCL2 (C-X-C motif chemokine ligand 2); and CXCL3 (C-X-C motif chemokine ligand 3).
