HGNC ID: 17761
Target Abstract:
Myeloid triggered receptor 2 (TREM2) is a single Ig structural domain receptor that is expressed in macrophages and dendritic cells, but not in granulocytes or monocytes. It is most abundantly expressed in the basal ganglia, corpus callosum, medulla oblongata, and spinal cord, whereas microglia in the CNS are the predominant cell type producing TREM2.TREM2 plays a role in chronic inflammation by stimulating constitutive, but not inflammatory, chemokine and cytokine production.TREM2 forms a receptor-signaling complex with TYROBP to activate the macrophage and dendritic cell immune response in macrophages and dendritic cells. It also associates with the splice protein DAP12 to transmit activation signals that play a role in innate and adaptive immune responses.TREM2 signaling is also an important pathway that promotes colonic wound healing.Mutations in TREM2 increase the risk of neurodegenerative diseases such as Alzheimer’s disease, amyotrophic lateral sclerosis, and Parkinson’s disease.
TREM2 Target Infomation Overview
- Target Symbol: TREM2, triggering receptor expressed on myeloid cells 2
- Gene Groups: V-set domain containing
- Alias: TREM-2; Trem2a; Trem2b; Trem2c
- Alias Names: triggering receptor expressed on myeloid cells 2a
TREM2, triggering receptor expressed on myeloid cells 2 Target Infomation by Species
- Human
- Mouse
- Rat
Human TREM2 Target Information
- Target Symbol: TREM2, triggering receptor expressed on myeloid cells 2
- Alias:
- PLOSL2
- TREM-2
- Trem2a
- Trem2b
- Trem2c
- triggering receptor expressed on monocytes 2
- triggering receptor expressed on myeloid cells 2a
- NCBI_Gene: 54209
- UniProtKB: Q9NZC2
Human TREM2 Predicted Functions
Enables several functions, including amyloid-beta binding activity; lipoprotein particle binding activity; and phospholipid binding activity. Involved in several processes, including positive regulation of protein localization; positive regulation of signal transduction; and regulation of neuroinflammatory response. Acts upstream of with a positive effect on memory and social behavior. Acts upstream of or within with a positive effect on CXCL12-activated CXCR4 signaling pathway. Acts upstream of or within negative regulation of NLRP3 inflammasome complex assembly; osteoclast differentiation; and positive regulation of macromolecule metabolic process. Located in plasma membrane. Is integral component of membrane and intrinsic component of plasma membrane. Part of plasma membrane raft. Biomarker of syphilis.
Mouse Trem2 Target Information
- Target Symbol: Trem2, triggering receptor expressed on myeloid cells 2
- Alias:
- Trem2a
- Trem2b
- Trem2c
- triggering receptor expressed on myeloid cells 2a
- triggering receptor expressed on myeloid cells 2b
- triggering receptor expressed on myeloid cells 2c
- NCBI_Gene: 83433
Mouse Trem2 Predicted Functions
Enables several functions, including lipopolysaccharide binding activity; lipoteichoic acid binding activity; and peptidoglycan binding activity. Involved in several processes, including regulation of cytokine production; regulation of signal transduction; and response to bacterium. Acts upstream of or within with a positive effect on defense response to Gram-negative bacterium. Acts upstream of or within with a negative effect on pyroptosis. Acts upstream of or within several processes, including negative regulation of NLRP3 inflammasome complex assembly; phagocytosis, engulfment; and social behavior. Located in plasma membrane. Is integral component of plasma membrane. Is expressed in central nervous system; embryo mesenchyme; genitourinary system; and limb interdigital region. Used to study frontotemporal dementia. Orthologous to human TREM2 (triggering receptor expressed on myeloid cells 2).
Rat Trem2 Target Information
- Target Symbol: Trem2, triggering receptor expressed on myeloid cells 2
- Alias:
- LOC301227
- Trem2-Mia
- Trem2-Mib
- NCBI_Gene: 301227
Rat Trem2 Predicted Functions
Predicted to enable several functions, including amyloid-beta binding activity; lipoprotein particle binding activity; and phospholipid binding activity. Involved in cellular response to glucose stimulus and cellular response to hypoxia. Predicted to be located in plasma membrane raft. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Orthologous to human TREM2 (triggering receptor expressed on myeloid cells 2).
