HGNC ID: 2169
Target Abstract:
Ciliary neurotrophic factor (CNTF) is a protein encoded by the CNTF gene in humans. Human CNTF is a single-chain polypeptide consisting of 200 amino acid residues, with a molecular weight of 22.7 kDa. The protein acts as a peptide hormone and its effects are limited to promoting neurotransmitter synthesis and axonal growth in certain neuronal populations within the nervous system. CNTF serves as an effective survival factor for neurons and oligodendrocytes and may be involved in reducing tissue damage during inflammatory episodes. It has also been demonstrated that CNTF can be expressed in bone surface cells and can decrease the activity of osteoblasts, contributing to bone metabolism.
CNTF Target Infomation Overview
- Target Symbol: CNTF, ciliary neurotrophic factor
- Gene Groups: Interleukin 6 type cytokine family
- Alias: HCNTF
- Alias Names: Ciliary Neuronotrophic Factor
CNTF, ciliary neurotrophic factor Target Infomation by Species
- Human
- Mouse
- Rat
Human CNTF Target Information
- Target Symbol: CNTF, ciliary neurotrophic factor
- Alias:
- Ciliary Neuronotrophic Factor
- HCNTF
- NCBI_Gene: 1270
- UniProtKB: P26441
Human CNTF Predicted Functions
Enables growth factor activity and interleukin-6 receptor binding activity. Involved in ciliary neurotrophic factor-mediated signaling pathway; negative regulation of neuron apoptotic process; and positive regulation of tyrosine phosphorylation of STAT protein. Acts upstream of or within positive regulation of gene expression. Predicted to be located in extracellular region. Predicted to be active in axon and extracellular space. Implicated in Huntington’s disease; disease of mental health; glaucoma; multiple sclerosis; and obesity. Biomarker of keratoconus.
Mouse Cntf Target Information
- Target Symbol: Cntf, ciliary neurotrophic factor
- Alias:
- AI429687
- expressed sequence AI429687
- NCBI_Gene: 12803
Mouse Cntf Predicted Functions
Predicted to enable signaling receptor binding activity. Acts upstream of or within several processes, including negative regulation of photoreceptor cell differentiation; positive regulation of tyrosine phosphorylation of STAT protein; and regulation of retinal cell programmed cell death. Located in extracellular space. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Huntington’s disease; disease of mental health; glaucoma; multiple sclerosis; and obesity. Orthologous to human CNTF (ciliary neurotrophic factor).
Rat Cntf Target Information
- Target Symbol: Cntf, ciliary neurotrophic factor
- Alias:
- ciliary neurotropic factor
- NCBI_Gene: 25707
Rat Cntf Predicted Functions
Enables ciliary neurotrophic factor receptor binding activity and cytokine activity. Involved in several processes, including membrane hyperpolarization; neurogenesis; and positive regulation of cell communication. Located in several cellular components, including axon; neuronal cell body; and plasma membrane bounded cell projection cytoplasm. Used to study Huntington’s disease and glaucoma. Biomarker of hyperglycemia and retinitis pigmentosa. Human ortholog(s) of this gene implicated in Huntington’s disease; disease of mental health; glaucoma; multiple sclerosis; and obesity. Orthologous to human CNTF (ciliary neurotrophic factor).
