HGNC ID: 2500
Target Abstract:
Connective tissue growth factor (CTGF) is a cell matrix protein in the CNN family. The extracellular portion of CTGF consists of four conserved, cysteine rich domains: the insulin-like growth factor binding protein (IGFBP) domain, the vascular hemophilia C-type repeat (vWC) domain, the platelet reactive protein type 1 repeat (TSR) domain, and the cysteine containing C-terminal domain (CT). CTGF plays an important role in many biological processes, including cell adhesion, migration, proliferation, angiogenesis, bone development, and tissue wound repair. Monitoring the level of CTGF in serum can provide more detailed insights into some pathological conditions, such as malignant tumors, diabetes nephropathy, retinopathy, fibrosis, arthritis, pancreatic cancer and cardiovascular diseases.
CCN2 Target Infomation Overview
- Target Symbol: CCN2, cellular communication network factor 2
- Gene Groups: Cellular communication network factors
- Alias: IGFBP8
- Previous Names: CTGF
- Alias Names: connective tissue growth factor
CCN2, cellular communication network factor 2 Target Infomation by Species
- Human
- Mouse
- Rat
Human CCN2 Target Information
- Target Symbol: CCN2, cellular communication network factor 2
- Alias:
- CCN family member 2
- connective tissue growth factor
- CTGF
- HCS24
- hypertrophic chondrocyte-specific protein 24
- IBP-8
- IGF-binding protein 8
- IGFBP-8
- IGFBP8
- insulin-like growth factor-binding protein 8
- MGC102839
- NOV2
- NCBI_Gene: 1490
- UniProtKB: P29279
Human CCN2 Predicted Functions
Enables protein C-terminus binding activity. Involved in positive regulation of MAPK cascade; positive regulation of cell differentiation; and positive regulation of stress fiber assembly. Colocalizes with collagen-containing extracellular matrix. Biomarker of ovarian cancer.
Mouse Ccn2 Target Information
- Target Symbol: Ccn2, cellular communication network factor 2
- Alias:
- connective tissue growth factor
- Ctgf
- fibroblast inducible secreted protein
- Fisp12
- Hcs24
- hypertrophic chondrocyte-specific gene product 24
- NCBI_Gene: 14219
Mouse Ccn2 Predicted Functions
Enables heparin binding activity and integrin binding activity. Acts upstream of or within several processes, including cartilage condensation; cell surface receptor signaling pathway; and chondrocyte proliferation. Located in extracellular matrix and extracellular region. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; sensory organ; and skeleton. Orthologous to human CCN2 (cellular communication network factor 2).
Rat Ccn2 Target Information
- Target Symbol: Ccn2, cellular communication network factor 2
- Alias:
- CCN family member 2
- connective tissue growth factor
- connective tissue growth-related protein
- Ctgf
- CTGRP
- NCBI_Gene: 64032
Rat Ccn2 Predicted Functions
Enables fibronectin binding activity and growth factor activity. Involved in several processes, including positive regulation of G0 to G1 transition; positive regulation of collagen biosynthetic process; and positive regulation of macromolecule metabolic process. Located in several cellular components, including cell cortex; cis-Golgi network; and perinuclear region of cytoplasm. Used to study endomyocardial fibrosis. Biomarker of several diseases, including artery disease (multiple); lung disease (multiple); membranoproliferative glomerulonephritis; primary biliary cholangitis; and restrictive cardiomyopathy (multiple). Orthologous to human CCN2 (cellular communication network factor 2).
