HGNC ID: 11187
SOS1 Target Infomation Overview
- Target Symbol: SOS1, SOS Ras/Rac guanine nucleotide exchange factor 1
- Gene Groups: Pleckstrin homology domain containing; Dbl family Rho GEFs
- Alias: HGF; GF1
- Previous Names: GINGF
- Alias Names: gingival fibromatosis, hereditary, 1; son of sevenless homolog 1 (Drosophila)
SOS1, SOS Ras/Rac guanine nucleotide exchange factor 1 Target Infomation by Species
- Human
- Mouse
- Rat
Human SOS1 Target Information
- Target Symbol: SOS1, SOS Ras/Rac guanine nucleotide exchange factor 1
- Alias:
- GF1
- GGF1
- GINGF
- gingival fibromatosis, hereditary, 1
- guanine nucleotide exchange factor
- HGF
- NS4
- son of sevenless homolog 1
- SOS-1
- NCBI_Gene: 6654
- UniProtKB: Q07889
Human SOS1 Predicted Functions
Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in axon guidance; cell surface receptor signaling pathway; and leukocyte migration. Predicted to act upstream of or within several processes, including animal organ development; regulation of T cell activation; and transmembrane receptor protein tyrosine kinase signaling pathway. Located in cytoplasm. Implicated in Noonan syndrome; Noonan syndrome 4; and gingival fibromatosis. Biomarker of cervical cancer and prostate cancer.
Mouse Sos1 Target Information
- Target Symbol: Sos1, SOS Ras/Rac guanine nucleotide exchange factor 1
- Alias:
- AI573415
- expressed sequence AI573415
- Sfpd
- Sftp4
- SP-D
- surfactant-associated protein 4
- NCBI_Gene: 20662
Mouse Sos1 Predicted Functions
Enables identical protein binding activity. Predicted to be involved in several processes, including induction of bacterial agglutination; negative regulation of interleukin-2 production; and regulation of phagocytosis. Predicted to act upstream of or within innate immune response and respiratory gaseous exchange by respiratory system. Located in cytoplasm. Is expressed in lung; otic capsule; and skeleton. Human ortholog(s) of this gene implicated in asthma; lung disease (multiple); respiratory syncytial virus infectious disease; and rhinitis. Orthologous to human SFTPD (surfactant protein D).
Rat Sos1 Target Information
- Target Symbol: Sos1, SOS Ras/Rac guanine nucleotide exchange factor 1
- Alias:
- LOC313845
- Son of sevenless homolog 1
- Son of sevenless homolog 1 (Drosophila)
- NCBI_Gene: 313845
Rat Sos1 Predicted Functions
Enables SH3 domain binding activity. Involved in Ras protein signal transduction; neurotrophin TRK receptor signaling pathway; and positive regulation of signal transduction. Located in neuronal cell body; plasma membrane; and postsynaptic density. Human ortholog(s) of this gene implicated in Noonan syndrome; Noonan syndrome 4; and gingival fibromatosis. Orthologous to human SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1).
