HGNC ID: 7808
Target Abstract:
Nerve growth factor (NGF) is a neuropeptide involved in regulating the growth, proliferation and survival of certain target neurons. When expressed, NGF initially exists as a 7S complex with a molecular weight of 130kDa consisting of three proteins, α-NGF, β-NGF, and γ-NGF(2:1:2 ratio). The term “nerve growth factor" usually refers to the 2.5S beta subunit protein with a molecular weight of 26kDa. The beta subunit is the only biologically active component of the 7SNGF complex (e.g. as a signaling molecule). NGF plays an important role in both innate and acquired immunity. Studies have shown that NGF circulates through plasma and is important for overall homeostasis maintenance. NGF promotes myelin repair and is also involved in a variety of psychiatric disorders, such as Alzheimer’s disease, depression, schizophrenia, autism, Rett syndrome, anorexia nervosa, bulimia nervosa. Dysregulation of NGF signaling is associated with Alzheimer’s disease. Similarly, NGF plays a role in many cardiovascular diseases, such as coronary atherosclerosis, obesity, type 2 diabetes, metabolic syndrome. NGF also promotes wound healing.
NGF Target Infomation Overview
- Target Symbol: NGF, nerve growth factor
- Gene Groups: Neurotrophins
- Previous Names: NGFB
- Alias Names: nerve growth factor (beta polypeptide)
NGF, nerve growth factor Target Infomation by Species
- Human
- Mouse
- Rat
Human NGF Target Information
- Target Symbol: NGF, nerve growth factor
- Alias:
- beta-nerve growth factor
- Beta-NGF
- HSAN5
- MGC161426
- MGC161428
- nerve growth factor (beta polypeptide)
- nerve growth factor, beta polypeptide
- nerve growth factor, beta subunit
- NGFB
- pro-nerve growth factor long
- NCBI_Gene: 4803
- UniProtKB: P01138
Human NGF Predicted Functions
Enables peptidase regulator activity and signaling receptor binding activity. Involved in extrinsic apoptotic signaling pathway via death domain receptors; neuron apoptotic process; and positive regulation of macromolecule metabolic process. Acts upstream of or within neuron projection morphogenesis. Predicted to be located in neuron projection terminus. Predicted to be active in several cellular components, including axon; dendrite; and synaptic vesicle. Implicated in IgA glomerulonephritis; asthma; end stage renal disease; hereditary sensory and autonomic neuropathy type 5; and interstitial cystitis. Biomarker of several diseases, including artery disease (multiple); interstitial cystitis; lung disease (multiple); neurogenic bladder; and obstructive sleep apnea.
Mouse Ngf Target Information
- Target Symbol: Ngf, nerve growth factor
- Alias:
- nerve growth factor, beta
- Ngfb
- NCBI_Gene: 18049
Mouse Ngf Predicted Functions
Enables transmembrane receptor protein tyrosine kinase activator activity. Involved in positive regulation of DNA binding activity; positive regulation of Ras protein signal transduction; and positive regulation of protein phosphorylation. Acts upstream of or within several processes, including cell surface receptor signaling pathway; positive regulation of cell projection organization; and positive regulation of macromolecule metabolic process. Located in neuron projection terminus. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; end stage renal disease; hereditary sensory and autonomic neuropathy type 5; interstitial cystitis; and neurogenic bladder. Orthologous to human NGF (nerve growth factor).
Rat Ngf Target Information
- Target Symbol: Ngf, nerve growth factor
- Alias:
- beta-nerve growth factor
- beta-NGF
- nerve growth factor (beta polypeptide)
- nerve growth factor, beta
- nerve growth factor, beta (mapped)
- Ngfb
- Ngfb_mapped
- pro-nerve growth factor long
- NCBI_Gene: 310738
Rat Ngf Predicted Functions
Predicted to enable nerve growth factor receptor binding activity; peptidase regulator activity; and signaling receptor activator activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; and response to ozone. Acts upstream of or within positive regulation of DNA-binding transcription factor activity; positive regulation of neurotrophin TRK receptor signaling pathway; and positive regulation of protein autophosphorylation. Located in extracellular space. Used to study bladder neck obstruction; cystitis; degenerative disc disease; and neurogenic bladder. Biomarker of several diseases, including diabetic neuropathy; hyperhomocysteinemia; mental depression; myofascial pain syndrome; and respiratory syncytial virus infectious disease. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; asthma; end stage renal disease; hereditary sensory and autonomic neuropathy type 5; and interstitial cystitis. Orthologous to human NGF (nerve growth factor).
