HGNC ID: 485
Target Abstract:
Angiopoietin-2 (ANG-2) is a secreted glycoprotein with a molecular weight of approximately 70 kDa. It has complex roles in angiogenesis, inflammation, and vascular development, and is expressed in endothelial cells, smooth muscle cells, pulmonary epithelial cells, differentiated myotubes, and neural precursor cells in highly vascularized tissues. ANG-2 promotes the survival, proliferation, and migration of endothelial cells and facilitates sprouting angiogenesis while inducing loss of perivascular cells and increasing vascular permeability. ANG-2 is essential for lymphatic vessel development and postnatal remodeling of both lymphatic and blood vessels.Patients with vascular tumors have elevated levels of ANG-2 in their bloodstream, and studies have shown that ANG-2 is involved in the pathogenesis of septic shock. The expression of ANG-2 in serum is associated with the growth of multiple myeloma, angiogenesis, and overall survival in oral squamous cell carcinoma. Circulating ANG-2 has been identified as a biomarker of early cardiovascular disease in children undergoing chronic dialysis, and capillary leak syndrome induced by Kaposi’s sarcoma-associated herpesvirus leads to rapid release of ANG-2 from endothelial cells.
ANGPT2 Target Infomation Overview
- Target Symbol: ANGPT2, angiopoietin 2
- Gene Groups: Receptor ligands; Fibrinogen C domain containing
- Alias: Ang2
ANGPT2, angiopoietin 2 Target Infomation by Species
- Human
- Mouse
- Rat
Human ANGPT2 Target Information
- Target Symbol: ANGPT2, angiopoietin 2
- Alias:
- AGPT2
- ANG-2
- ANG2
- angiopoietin-2
- angiopoietin-2a
- angiopoietin-2B
- LMPHM10
- Tie2-ligand
- NCBI_Gene: 285
- UniProtKB: O15123
Human ANGPT2 Predicted Functions
Enables receptor tyrosine kinase binding activity. Involved in Tie signaling pathway; negative regulation of blood vessel endothelial cell migration; and negative regulation of positive chemotaxis. Acts upstream of or within gene expression. Located in extracellular space. Implicated in hereditary lymphedema. Biomarker of COVID-19; endometrial adenocarcinoma; transitional cell carcinoma; and type 2 diabetes mellitus.
Mouse Angpt2 Target Information
- Target Symbol: Angpt2, angiopoietin 2
- Alias:
- Ang-2
- Ang2
- NCBI_Gene: 11601
Mouse Angpt2 Predicted Functions
Predicted to enable receptor tyrosine kinase binding activity. Acts upstream of or within angiogenesis; negative regulation of angiogenesis; and negative regulation of cell-substrate adhesion. Located in extracellular space. Is expressed in several structures, including cardiovascular system; central nervous system; hemolymphoid system; limb interdigital region; and urinary system. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human ANGPT2 (angiopoietin 2).
Rat Angpt2 Target Information
- Target Symbol: Angpt2, angiopoietin 2
- Alias:
- Agpt2
- Ang-2
- angiopoietin-2
- NCBI_Gene: 89805
- UniProtKB: O35462
Rat Angpt2 Predicted Functions
Predicted to enable receptor tyrosine kinase binding activity. Involved in several processes, including blood vessel development; maternal process involved in female pregnancy; and positive regulation of angiogenesis. Located in several cellular components, including extracellular space; nucleus; and plasma membrane. Used to study several diseases, including ischemia (multiple); membranoproliferative glomerulonephritis; portal hypertension; retinal disease (multiple); and uremia. Biomarker of several diseases, including Caroli disease; artery disease (multiple); glomerulonephritis (multiple); musculoskeletal system cancer (multiple); and retinal disease (multiple). Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human ANGPT2 (angiopoietin 2).
