HGNC ID: 7166
Target Abstract:
Matrix metalloproteinase 2(MMP-2), also known as 72kDa type IV collagenase and gelatin A, is encoded by the MMP2 gene in humans. Activation of MMP-2 requires proteolytic processing. MMP-2 plays a role in endometrial rupture, regulation of vascularization and inflammatory response. MMP-2 is involved in many events, such as cancer progression, cancer cell invasion, cell signaling, neovascularization, and lymphangiogenesis. MMP2 gene mutation is associated with Torg-Winchester syndrome, multiple osteolysis, arthritis syndrome, and possibly keloid. In non-cystic fibrotic bronchiectasis, MMP-2 concentrations were elevated in patients infected with Haemophilus influenzae compared to patients with respiratory infection with Pseudomonas aeruginosa.
MMP2 Target Infomation Overview
- Target Symbol: MMP2, matrix metallopeptidase 2
- Gene Groups: M10 matrix metallopeptidases
- Alias: TBE-1
- Previous Names: CLG4; CLG4A
- Alias Names: matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
MMP2, matrix metallopeptidase 2 Target Infomation by Species
- Human
- Mouse
- Rat
Human MMP2 Target Information
- Target Symbol: MMP2, matrix metallopeptidase 2
- Alias:
- 72 kDa gelatinase
- 72 kDa type IV collagenase
- CLG4
- CLG4A
- collagenase type IV-A
- gelatinase A
- matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
- matrix metalloproteinase 2 (gelatinase a, 72kda gelatinase, 72kda type iv collagenase)
- matrix metalloproteinase-2
- matrix metalloproteinase-II
- MMP-2
- MMP-II
- MONA
- neutrophil gelatinase
- TBE-1
- NCBI_Gene: 4313
- UniProtKB: P08253
Human MMP2 Predicted Functions
Enables metallopeptidase activity and serine-type endopeptidase activity. Involved in several processes, including cellular response to UV-A; endodermal cell differentiation; and positive regulation of vascular associated smooth muscle cell proliferation. Located in extracellular space. Colocalizes with collagen-containing extracellular matrix. Implicated in artery disease (multiple); eye disease (multiple); pseudoxanthoma elasticum; and temporal arteritis. Biomarker of several diseases, including artery disease (multiple); carcinoma (multiple); cardiomyopathy (multiple); cholesteatoma (multiple); and neurodegenerative disease (multiple).
Mouse Mmp2 Target Information
- Target Symbol: Mmp2, matrix metallopeptidase 2
- Alias:
- 72kDa gelatinase
- 72kDa type IV collagenase
- Clg4a
- collagenase IVA, basement membrane, 72 kDa
- GelA
- gelatinase A
- MMP-2
- NCBI_Gene: 17390
Mouse Mmp2 Predicted Functions
Enables metalloendopeptidase activity. Involved in response to amyloid-beta. Acts upstream of or within several processes, including blood vessel maturation; bone trabecula formation; and collagen catabolic process. Located in several cellular components, including extracellular space; mitochondrion; and sarcomere. Is expressed in several structures, including embryo mesenchyme; genitourinary system; heart; jaw; and musculoskeletal system. Human ortholog(s) of this gene implicated in artery disease (multiple); eye disease (multiple); pseudoxanthoma elasticum; and temporal arteritis. Orthologous to human MMP2 (matrix metallopeptidase 2).
Rat Mmp2 Target Information
- Target Symbol: Mmp2, matrix metallopeptidase 2
- Alias:
- 72 kDa gelatinase
- 72 KDa type IV collagenase
- gelatinase A
- matrix metalloproteinase 2
- matrix metalloproteinase 2 (72 KDa type IV collagenase)
- matrix metalloproteinase-2
- MMP-2
- NCBI_Gene: 81686
Rat Mmp2 Predicted Functions
Enables fibronectin binding activity and peptidase activity. Involved in several processes, including cellular response to estradiol stimulus; circulatory system development; and reproductive structure development. Located in cytoplasm and extracellular space. Used to study artery disease (multiple); conjunctivitis; and transient cerebral ischemia. Biomarker of several diseases, including acute necrotizing pancreatitis; artery disease (multiple); bile duct disease (multiple); brain ischemia (multiple); and liver cirrhosis (multiple). Human ortholog(s) of this gene implicated in artery disease (multiple); eye disease (multiple); pseudoxanthoma elasticum; and temporal arteritis. Orthologous to human MMP2 (matrix metallopeptidase 2).
