HGNC ID: 6307
Target Abstract:
Vascular endothelial growth factor receptor 2 (VEGFR2), also known as kinase insertion region receptor (KDR), is a member of the class III subfamily of tyrosine kinase receptors (RTKs). VEGFR2 is more widely distributed and expressed in say to vascular derived endothelial cells than VEGFR1. VEGFR2 binds to VEGF-A (VEGF121, VEGF165, VEGF189 and VEGF206 shear variants), VEGF-C and VEGF-D. The difference between soluble VEGFR1 and VEGFR2 in blocking VEGF-induced cell proliferation and migration was highly significant. Soluble VEGFR2, in contrast to soluble VEGFR1, was unable to compete with VEGF for binding to endothelial cells expressing both VEGFR1 and VEGFR2. Soluble VEGFR2 only partially inhibits cell migration, whereas soluble VEGFR1 almost completely blocks VEGF-induced cell proliferation and migration.Binding of VEGF to soluble VEGFR2, but not to VEGFR1, is also dependent on heparin.The VEGF/VEGFR2 signaling pathway has an important role in oncogenesis and other pathologic angiogenic diseases. Inactivation of functional VEGFR2 function using blocking antibodies disrupts angiogenesis and prevents tumor cell spread.
KDR Target Infomation Overview
- Target Symbol: KDR, kinase insert domain receptor
- Gene Groups: Receptor tyrosine kinases; CD molecules; V-set domain containing; I-set domain containing
- Alias: FLK1; VEGFR; VEGFR2; CD309
- Alias Names: vascular endothelial growth factor receptor 2; fetal liver kinase 1; kinase insert domain receptor (a type III receptor tyrosine kinase)
KDR, kinase insert domain receptor Target Infomation by Species
- Human
- Mouse
- Rat
Human KDR Target Information
- Target Symbol: KDR, kinase insert domain receptor
- Alias:
- CD309
- fetal liver kinase 1
- fetal liver kinase-1
- FLK1
- kinase insert domain receptor (a type III receptor tyrosine kinase)
- protein-tyrosine kinase receptor Flk-1
- soluble VEGFR2
- tyrosine kinase growth factor receptor
- vascular endothelial growth factor receptor 2
- VEGFR
- VEGFR2
- NCBI_Gene: 3791
- UniProtKB: P35968
Human KDR Predicted Functions
Enables several functions, including cell adhesion molecule binding activity; vascular endothelial growth factor binding activity; and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including intracellular signal transduction; positive regulation of endothelial cell migration; and protein phosphorylation. Acts upstream of or within several processes, including branching involved in blood vessel morphogenesis; positive regulation of mitochondrial depolarization; and positive regulation of mitochondrial fission. Located in several cellular components, including Golgi apparatus; endosome; and membrane raft. Is integral component of plasma membrane. Implicated in several diseases, including artery disease (multiple); gastrointestinal system cancer (multiple); glioblastoma; macular degeneration (multiple); and pancreatic cancer (multiple). Biomarker of several diseases, including breast cancer (multiple); carcinoma (multiple); cerebrovascular disease (multiple); eye disease (multiple); and systemic scleroderma (multiple).
Mouse Kdr Target Information
- Target Symbol: Kdr, kinase insert domain protein receptor
- Alias:
- fetal liver kinase 1
- Flk-1
- Flk1
- orv
- orvieto
- vascular endothelial growth factor receptor- 2
- VEGF receptor-2
- VEGFR-2
- VEGFR2
- NCBI_Gene: 16542
Mouse Kdr Predicted Functions
Enables growth factor binding activity and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including circulatory system development; peptidyl-tyrosine autophosphorylation; and positive regulation of vasculogenesis. Acts upstream of or within several processes, including animal organ development; positive regulation of cell population proliferation; and vasculature development. Located in several cellular components, including cell junction; endosome; and external side of plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; extraembryonic component; and genitourinary system. Human ortholog(s) of this gene implicated in several diseases, including adhesions of uterus; artery disease (multiple); gastrointestinal system cancer (multiple); macular degeneration (multiple); and pancreatic cancer (multiple). Orthologous to human KDR (kinase insert domain receptor).
Rat Kdr Target Information
- Target Symbol: Kdr, kinase insert domain receptor
- Alias:
- fetal liver kinase 1
- FLK-1
- FLK1 kinase insert domain receptor (a type III receptor tyrosine kinase) (VEGF receptor 2)
- FLK1 kinase insert domain receptor (VEGF receptor 2)
- kinase insert domain protein receptor
- MGC93590
- protein-tyrosine kinase receptor flk-1
- vascular endothelial growth factor receptor 2
- Vegfr-2
- NCBI_Gene: 25589
Rat Kdr Predicted Functions
Enables growth factor binding activity and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including generation of neurons; positive regulation of endothelial cell proliferation; and positive regulation of intracellular signal transduction. Located in several cellular components, including neuron projection; neuronal cell body; and plasma membrane. Used to study adhesions of uterus; brain ischemia; cystitis; and myocardial infarction. Biomarker of several diseases, including artery disease (multiple); impotence; ovarian hyperstimulation syndrome; prostate disease (multiple); and retinopathy of prematurity. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); gastrointestinal system cancer (multiple); glioblastoma; macular degeneration (multiple); and pancreatic cancer (multiple). Orthologous to human KDR (kinase insert domain receptor).
