HGNC ID: 7155
Target Abstract:
Matrix metalloproteinase 1(MMP-1), also known as interstitial collagenase and fibroblast collagenase, is encoded by the MMP1 gene in humans. MMP-1 is produced by fibroblasts, chondrocytes, macrophages, keratinocytes, endothelial cells, and osteoblasts. Its production is upregulated by a variety of stimuli including cytokines (such as EGF, interleukin, and TNF-α) and chemicals, and is inhibited by TIMP-1, TIMP-2, and α2-macroglobulin. MMP-1 plays an important role in the degradation of collagen fibers in extracellular matrix remodeling and is involved in a variety of biological processes including rheumatoid arthritis, osteoarthritis, periodontal disease, tumor invasion, angiogenesis, corneal ulcers, tissue remodeling, inflammatory bowel disease, atherosclerosis, and aneurysms. In addition, MMP-1 also lyses a variety of substrates such as casein, gelatin, proteoglycan, endogenous hormone, tumor promoting necrosis factor, and chondroconnexin.
MMP1 Target Infomation Overview
- Target Symbol: MMP1, matrix metallopeptidase 1
- Gene Groups: Receptor ligands; M10 matrix metallopeptidases
- Previous Names: CLG
- Alias Names: interstitial collagenase; matrix metalloproteinase 1 (interstitial collagenase)
MMP1, matrix metallopeptidase 1 Target Infomation by Species
- Human
- Mouse
- Rat
Human MMP1 Target Information
- Target Symbol: MMP1, matrix metallopeptidase 1
- Alias:
- CLG
- CLGN
- fibroblast collagenase
- interstitial collagenase
- matrix metallopeptidase 1 (interstitial collagenase)
- matrix metalloprotease 1
- matrix metalloproteinase 1
- matrix metalloproteinase 1 (interstitial collagenase)
- NCBI_Gene: 4312
- UniProtKB: P03956
Human MMP1 Predicted Functions
Enables metalloendopeptidase activity. Involved in cellular response to UV-A; positive regulation of protein-containing complex assembly; and proteolysis. Predicted to be located in extracellular region. Implicated in several diseases, including artery disease (multiple); female reproductive organ cancer (multiple); intrinsic cardiomyopathy (multiple); obstructive lung disease (multiple); and urinary system cancer (multiple). Biomarker of several diseases, including artery disease (multiple); arthritis (multiple); idiopathic pulmonary fibrosis; immunoglobulin light chain amyloidosis; and systemic lupus erythematosus.
Mouse Mmp1a Target Information
- Target Symbol: Mmp1a, matrix metallopeptidase 1a (interstitial collagenase)
- Alias:
- Mcol-A
- NCBI_Gene: 83995
Mouse Mmp1a Predicted Functions
Predicted to enable metalloendopeptidase activity. Predicted to be involved in collagen catabolic process and extracellular matrix organization. Is expressed in several structures, including extraembryonic component and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); female reproductive organ cancer (multiple); intrinsic cardiomyopathy (multiple); obstructive lung disease (multiple); and urinary system cancer (multiple). Orthologous to human MMP1 (matrix metallopeptidase 1).
Rat Mmp1 Target Information
- Target Symbol: Mmp1, matrix metallopeptidase 1
- Alias:
- Clgn
- fibroblast collagenase
- interstitial collagenase
- LOC300339
- matrix metallopeptidase 1 (interstitial collagenase)
- matrix metallopeptidase 1a
- matrix metallopeptidase 1a (interstitial collagenase)
- matrix metalloproteinase 1
- matrix metalloproteinase 1a (interstitial collagenase)
- matrix metalloproteinase-1
- MMP-1
- Mmp1a
- myocardial collagenase
- NCBI_Gene: 300339
Rat Mmp1 Predicted Functions
Enables peptidase activity. Involved in several processes, including cellular response to cytokine stimulus; female gonad development; and positive regulation of cell migration. Located in cytoplasm and extracellular space. Used to study several diseases, including artery disease (multiple); degenerative disc disease; liver cirrhosis; pulmonary fibrosis; and ulcerative colitis. Biomarker of several diseases, including chronic obstructive pulmonary disease; liver cirrhosis; scoliosis; tendinitis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); female reproductive organ cancer (multiple); intrinsic cardiomyopathy (multiple); obstructive lung disease (multiple); and urinary system cancer (multiple). Orthologous to human MMP1 (matrix metallopeptidase 1).
