HGNC ID: 10672
Target Abstract:
The chemokine CXC ligand 12 (CXCL12), also known as stromal cell-derived factor 1 (SDF-1), is a chemokine protein that activates leukocytes and is usually induced by pro-inflammatory stimulants, such as LPS, TNF, or IL-1.CXCL12 is strongly chemotactic for lymphocytes. During embryogenesis, it induces hematopoietic cell migration from the fetal liver to the bone marrow and the formation of large blood vessels. In adults, CXCL12 has an important role in angiogenesis, where it recruits endothelial progenitor cells (EPCs) in the bone marrow through a CXCR4-dependent mechanism.CXCL12 also has a role in tumor metastasis, where cancer cells expressing the CXCR4 receptor are attracted to the target tissue. However, in breast cancer, elevated CXCL12 expression suggests a reduced risk of distal metastasis.
CXCL12 Target Infomation Overview
- Target Symbol: CXCL12, C-X-C motif chemokine ligand 12
- Gene Groups: Chemokine ligands
- Alias: SCYB12; SDF-1a; SDF-1b; PBSF; TLSF-a; TLSF-b; TPAR1
- Previous Names: SDF1A; SDF1B; SDF1
- Alias Names: stromal cell-derived factor 1; chemokine (C-X-C motif) ligand 12
CXCL12, C-X-C motif chemokine ligand 12 Target Infomation by Species
- Human
- Mouse
- Rat
Human CXCL12 Target Information
- Target Symbol: CXCL12, C-X-C motif chemokine ligand 12
- Alias:
- chemokine (C-X-C motif) ligand 12
- intercrine reduced in hepatomas
- IRH
- PBSF
- pre-B cell growth-stimulating factor
- SCYB12
- SDF-1a
- SDF-1b
- SDF1
- SDF1A
- SDF1B
- stromal cell-derived factor 1
- TLSF
- TLSF-a
- TLSF-b
- TPAR1
- NCBI_Gene: 6387
- UniProtKB: P48061
Human CXCL12 Predicted Functions
Enables CXCR chemokine receptor binding activity; chemokine activity; and integrin binding activity. Involved in several processes, including integrin activation; negative regulation of apoptotic process; and regulation of leukocyte migration. Acts upstream of or within positive regulation of T cell migration and positive regulation of cell adhesion. Located in extracellular exosome. Part of collagen-containing extracellular matrix. Implicated in breast carcinoma; diabetic angiopathy; human immunodeficiency virus infectious disease; and type 1 diabetes mellitus. Biomarker of diabetic retinopathy; insulinoma; periodontitis; and type 2 diabetes mellitus.
Mouse Cxcl12 Target Information
- Target Symbol: Cxcl12, chemokine (C-X-C motif) ligand 12
- Alias:
- AI174028
- expressed sequence AI174028
- PBSF
- PBSF/SDF-1
- Scyb12
- SDF-1
- Sdf1
- Sdf1a
- Sdf1b
- stromal cell derived factor 1
- stromal cell derived factor 1A
- stromal cell derived factor 1B
- TLSF-a
- TLSF-b
- TPAR1
- NCBI_Gene: 20315
Mouse Cxcl12 Predicted Functions
Enables chemokine activity. Involved in dopaminergic neuron differentiation. Acts upstream of or within several processes, including gamete generation; nervous system development; and positive regulation of intracellular signal transduction. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in breast carcinoma; diabetic angiopathy; human immunodeficiency virus infectious disease; and type 1 diabetes mellitus. Orthologous to human CXCL12 (C-X-C motif chemokine ligand 12).
Rat Cxcl12 Target Information
- Target Symbol: Cxcl12, C-X-C motif chemokine ligand 12
- Alias:
- chemokine (C-X-C motif) ligand 12
- chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)
- SDF-1 gamma
- Sdf1
- Stromal cell-derived factor 1
- stromal cell-derived factor-1 gamma
- NCBI_Gene: 24772
Rat Cxcl12 Predicted Functions
Predicted to enable CXCR chemokine receptor binding activity; chemokine activity; and integrin binding activity. Involved in several processes, including detection of stimulus involved in sensory perception of pain; nervous system development; and regulation of ion transport. Located in several cellular components, including extracellular space; nucleus; and plasma membrane. Used to study myocardial infarction. Biomarker of anti-basement membrane glomerulonephritis; brain ischemia; myocardial infarction; status epilepticus; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in breast carcinoma; diabetic angiopathy; human immunodeficiency virus infectious disease; and type 1 diabetes mellitus. Orthologous to human CXCL12 (C-X-C motif chemokine ligand 12).
