HGNC ID: 15582
Target Abstract:
Carcinoma antigen 125 or glycan antigen 125 (CA125), also known as mucin 16 or MUC16, is a protein that in humans is encoded by the MUC16 gene.MUC16 is a member of the mucin family of glycoproteins. It is a component of the epithelium of the ocular surface, respiratory tract, and female reproductive tract. Because MUC16 is highly glycosylated, it forms a hydrophilic environment in the apical membrane of epithelial cells, which serves as a lubricating barrier against foreign particles and infectious agents. In addition, the cytoplasmic terminus of MUC16 has been shown to interact with the cytoskeleton by binding to members of the ERM family of proteins.MUC16 expression is altered in dry eye, cystic fibrosis, and several cancers.
MUC16 Target Infomation Overview
- Target Symbol: MUC16, mucin 16, cell surface associated
- Gene Groups: Mucins
- Alias: CA125; FLJ14303; CA-125
- Alias Names: cancer antigen 125
MUC16, mucin 16, cell surface associated Target Infomation by Species
- Human
- Mouse
- Rat
Human MUC16 Target Information
- Target Symbol: MUC16, mucin 16, cell surface associated
- Alias:
- CA-125
- CA125
- CA125 ovarian cancer antigen
- cancer antigen 125
- FLJ14303
- MUC-16
- mucin 16
- mucin-16
- mucin-16 long isoform
- mucin-16 short isoform
- ovarian cancer-related tumor marker CA125
- ovarian carcinoma antigen CA125
- NCBI_Gene: 94025
- UniProtKB: Q8WXI7
Human MUC16 Predicted Functions
Predicted to act upstream of or within negative regulation of epithelial cell proliferation; negative regulation of interleukin-6 production; and negative regulation of wound healing. Is extrinsic component of membrane. Implicated in ovarian cancer. Biomarker of Sjogren’s syndrome; cholangiocarcinoma; dry eye syndrome; keratoconjunctivitis; and pancreatic cancer.
Mouse Muc16 Target Information
- Target Symbol: Muc16, mucin 16
- Alias:
- 1110008I14Rik
- gene model 1480, (NCBI)
- Gm1480
- Gm21044
- LOC385009
- predicted gene, 21044
- RIKEN cDNA 1110008I14 gene
- NCBI_Gene: 73732
Mouse Muc16 Predicted Functions
Acts upstream of or within negative regulation of epithelial cell proliferation; negative regulation of interleukin-6 production; and negative regulation of wound healing. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; mesothelium; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to human MUC16 (mucin 16, cell surface associated).
Rat Muc16 Target Information
- Target Symbol: Muc16, mucin 16, cell surface associated
- Alias:
- LOC315451
- mucin 16
- mucin-16
- RGD1308422
- similar to ovarian cancer related tumor marker CA125
- NCBI_Gene: 315451
- 暂无
Rat Muc16 Predicted Functions
Predicted to act upstream of or within negative regulation of epithelial cell proliferation; negative regulation of interleukin-6 production; and negative regulation of wound healing. Located in extracellular space. Biomarker of ovarian carcinoma. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to human MUC16 (mucin 16, cell surface associated).
