HGNC ID: 10721
Target Abstract:
CD62P is a 140-kDa transmembrane glycoprotein also known as P-Selectin.P-Selectin is stored in the alpha granules of platelets and the Weibel-Palade vesicles of endothelial cells and is rapidly translocated to the plasma membrane upon activation. In the inflammatory response, P-Selectin is thought to mediate the initial adhesion interactions of neutrophils and monocytes with the endothelium; during hemostasis, activated platelets interact with neutrophils and monocytes.
SELP Target Infomation Overview
- Target Symbol: SELP, selectin P
- Gene Groups: CD molecules; Selectins; Sushi domain containing; C-type lectin domain containing
- Alias: CD62; PSEL; PADGEM; GMP140; CD62P
- Previous Names: GRMP
- Alias Names: antigen CD62; granule membrane protein 140kDa; selectin P (granule membrane protein 140kD, antigen CD62); selectin P (granule membrane protein 140kDa, antigen CD62)
SELP, selectin P Target Infomation by Species
- Human
- Mouse
- Rat
Human SELP Target Information
- Target Symbol: SELP, selectin P
- Alias:
- CD62
- CD62 antigen-like family member P
- CD62P
- FLJ45155
- GMP-140
- GMP140
- granule membrane protein 140
- granule membrane protein 140kDa
- granulocyte membrane protein
- GRMP
- LECAM3
- leukocyte-endothelial cell adhesion molecule 3
- P-selectin
- PADGEM
- platelet activation dependent granule-external membrane protein
- platelet alpha-granule membrane protein
- PSEL
- selectin P (granule membrane protein 140kDa, antigen CD62)
- NCBI_Gene: 6403
- UniProtKB: P16109
Human SELP Predicted Functions
Enables several functions, including fucose binding activity; heparin binding activity; and lipopolysaccharide binding activity. Involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; calcium-mediated signaling using intracellular calcium source; and leukocyte tethering or rolling. Located in external side of plasma membrane; extracellular space; and platelet alpha granule membrane. Is integral component of plasma membrane. Implicated in atopic dermatitis and myocardial infarction. Biomarker of several diseases, including Kawasaki disease; autoimmune disease (multiple); coronary artery disease (multiple); obesity; and type 2 diabetes mellitus.
Mouse Selp Target Information
- Target Symbol: Selp, selectin, platelet
- Alias:
- CD62P
- granulocyte membrane protein
- Grmp
- P-selectin
- NCBI_Gene: 20344
Mouse Selp Predicted Functions
Enables calcium-dependent protein binding activity and sialic acid binding activity. Involved in positive regulation of leukocyte tethering or rolling and positive regulation of platelet activation. Acts upstream of or within several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; leukocyte tethering or rolling; and positive regulation of leukocyte migration. Located in external side of plasma membrane. Is expressed in blood and liver. Human ortholog(s) of this gene implicated in atopic dermatitis and myocardial infarction. Orthologous to human SELP (selectin P).
Rat Selp Target Information
- Target Symbol: Selp, selectin P
- Alias:
- CD62 antigen-like family member P
- GMP-140
- granule membrane protein 140
- LECAM3
- leukocyte-endothelial cell adhesion molecule 3
- MGC124632
- P-selectin
- PADGEM
- platelet activation dependent granule-external membrane protein
- PSELECT
- Selectin platelet
- selectin, platelet
- NCBI_Gene: 25651
Rat Selp Predicted Functions
Predicted to enable several functions, including fucose binding activity; heparin binding activity; and lipopolysaccharide binding activity. Involved in several processes, including leukocyte migration; regulation of cellular extravasation; and response to lipopolysaccharide. Located in external side of plasma membrane and extracellular space. Used to study acute necrotizing pancreatitis and anti-basement membrane glomerulonephritis. Biomarker of atherosclerosis; colitis; congestive heart failure; and myocardial infarction. Human ortholog(s) of this gene implicated in atopic dermatitis and myocardial infarction. Orthologous to human SELP (selectin P).
