HGNC ID: 1639
Target Abstract:
CD2, also known as LFA-2, is a approximately 50kDa glycoprotein and a member of the Ig superfamily. CD2 serves as the receptor for CD58 in the human body. It is expressed on the surface of 80-90% of peripheral blood lymphocytes, subsets of NK cells, and all mature T cells. CD2 plays a significant role in T cell signaling and lymphocyte adhesion.
CD2 Target Infomation Overview
- Target Symbol: CD2, CD2 molecule
- Gene Groups: CD molecules; V-set domain containing; C2-set domain containing; Ig-like cell adhesion molecule family
- Previous Names: SRBC
- Alias Names: CD2 antigen (p50), sheep red blood cell receptor
CD2, CD2 molecule Target Infomation by Species
- Human
- Mouse
- Rat
Human CD2 Target Information
- Target Symbol: CD2, CD2 molecule
- Alias:
- cd2 antigen
- CD2 antigen (p50), sheep red blood cell receptor
- erythrocyte receptor
- FLJ46032
- LFA-2
- LFA-3 receptor
- lymphocyte-function antigen-2
- rosette receptor
- SRBC
- T-cell surface antigen CD2
- T-cell surface antigen T11/Leu-5
- T11
- NCBI_Gene: 914
- UniProtKB: P06729
Human CD2 Predicted Functions
Enables signaling receptor binding activity. Involved in heterotypic cell-cell adhesion and positive regulation of cytokine production. Located in external side of plasma membrane.
Mouse Cd2 Target Information
- Target Symbol: Cd2, CD2 antigen
- Alias:
- LFA-2
- Ly-37
- Ly37
- lymphocyte antigen 37
- NCBI_Gene: 12481
Mouse Cd2 Predicted Functions
Enables identical protein binding activity. Predicted to be involved in T cell activation; heterotypic cell-cell adhesion; and positive regulation of cytokine production. Located in several cellular components, including cell-cell junction; cytoplasmic side of plasma membrane; and external side of plasma membrane. Is anchored component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human CD2 (CD2 molecule).
Rat Cd2 Target Information
- Target Symbol: Cd2, Cd2 molecule
- Alias:
- CD2 antigen
- CD2R
- LFA-2
- LFA-3 receptor
- LFA2
- OX-34
- OX-34 antigen
- OX-45 surface antigen homolog to human T lymphocyte CD2 antigen
- OX-45 surface antigen, homolog to human T lymphocyte CD2 antigen
- OX34
- T-cell surface antigen CD2
- T-cell surface antigen T11/Leu-5
- NCBI_Gene: 497761
- UniProtKB: P08921
Rat Cd2 Predicted Functions
Enables identical protein binding activity; protein self-association; and receptor tyrosine kinase binding activity. Involved in T cell activation and cell-cell adhesion. Located in cell surface and membrane raft. Part of protein-containing complex. Orthologous to human CD2 (CD2 molecule).