HGNC ID: 10615
Target Abstract:
Chemokine ligand (CCL17), also known as thymus activation-regulated chemokine (TARC), is a small molecular weight cytokine of the CC chemokine family.The gene encoding CCL17 is located on chromosome 16 in humans, along with the other chemokines CCL22 and CX3CL1.CCL17 is constitutively expressed in the thymus, and transiently expressed in phytohaemagglutinin (PHA)-stimulated peripheral blood individual nuclei. nuclei are transiently expressed in peripheral blood mononuclear cells stimulated by phytohemagglutinin (PHA). This chemokine specifically binds to T cells and exhibits chemotaxis by binding to the chemokine receptor CCR4.
CCL17 Target Infomation Overview
- Target Symbol: CCL17, C-C motif chemokine ligand 17
- Gene Groups: Chemokine ligands
- Alias: TARC; ABCD-2
- Previous Names: SCYA17
- Alias Names: small inducible cytokine subfamily A (Cys-Cys), member 17; chemokine (C-C motif) ligand 17
CCL17, C-C motif chemokine ligand 17 Target Infomation by Species
- Human
- Mouse
- Rat
Human CCL17 Target Information
- Target Symbol: CCL17, C-C motif chemokine ligand 17
- Alias:
- A-152E5.3
- ABCD-2
- C-C motif chemokine 17
- CC chemokine TARC
- chemokine (C-C motif) ligand 17
- MGC138271
- MGC138273
- SCYA17
- small inducible cytokine subfamily A (Cys-Cys), member 17
- small-inducible cytokine A17
- T cell-directed CC chemokine
- TARC
- thymus and activation-regulated chemokine
- NCBI_Gene: 6361
- UniProtKB: Q92583
Human CCL17 Predicted Functions
Predicted to enable CCR chemokine receptor binding activity and chemokine activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide and killing of cells of other organism. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Biomarker of several diseases, including allergic bronchopulmonary aspergillosis; cystic fibrosis; lung disease (multiple); pulmonary eosinophilia; and respiratory syncytial virus infectious disease.
Mouse Ccl17 Target Information
- Target Symbol: Ccl17, chemokine (C-C motif) ligand 17
- Alias:
- ABCD-2
- Scya17
- small inducible cytokine subfamily A17
- TARC
- NCBI_Gene: 20295
Mouse Ccl17 Predicted Functions
Predicted to enable CCR4 chemokine receptor binding activity and chemokine activity. Acts upstream of or within negative regulation of myoblast differentiation. Predicted to be active in extracellular space. Is expressed in Sertoli cell; central nervous system; hemolymphoid system; and retina. Orthologous to human CCL17 (C-C motif chemokine ligand 17).
Rat Ccl17 Target Information
- Target Symbol: Ccl17, C-C motif chemokine ligand 17
- Alias:
- C-C motif chemokine 17
- chemokine (C-C motif) ligand 17
- Scya17
- small inducible cytokine subfamily A (Cys-Cys), member 17
- Tarc
- NCBI_Gene: 117518
Rat Ccl17 Predicted Functions
Enables CCR4 chemokine receptor binding activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; leukocyte chemotaxis; and positive regulation of ERK1 and ERK2 cascade. Predicted to act upstream of or within negative regulation of myoblast differentiation. Predicted to be active in extracellular space. Biomarker of anti-basement membrane glomerulonephritis; asthma; pneumonia; and pulmonary fibrosis. Orthologous to human CCL17 (C-C motif chemokine ligand 17).
