HGNC ID: 1633
Target Abstract:
CD19 is a 95kDa transmembrane glycoprotein that belongs to the immunoglobulin superfamily. It is expressed in various stages of B cell development, except for plasma cells. CD19 forms a complex with CD21, CD81, and MHC II molecules and plays a role in the activation of immature B cells through interaction with the B cell receptor. CD19 promotes B cell proliferation, development, and activation, as well as the maturation of memory B cells. In mice lacking CD19, both bone marrow and peripheral B cell generation and maturation are impaired.
CD19 Target Infomation Overview
- Target Symbol: CD19, CD19 molecule
- Gene Groups: CD molecules; Immunoglobulin like domain containing; Minor histocompatibility antigens
- Alias Names: CD19 antigen
CD19, CD19 molecule Target Infomation by Species
- Human
- Mouse
- Rat
Human CD19 Target Information
- Target Symbol: CD19, CD19 molecule
- Alias:
- B-lymphocyte antigen CD19
- B-lymphocyte surface antigen B4
- B4
- cd19 antigen
- CVID3
- differentiation antigen CD19
- MGC12802
- T-cell surface antigen Leu-12
- NCBI_Gene: 930
- UniProtKB: P15391
Human CD19 Predicted Functions
Involved in several processes, including B cell proliferation involved in immune response; positive regulation of phosphatidylinositol 3-kinase activity; and positive regulation of release of sequestered calcium ion into cytosol. Located in external side of plasma membrane. Is integral component of plasma membrane. Part of protein-containing complex. Implicated in common variable immunodeficiency.
Mouse Cd19 Target Information
- Target Symbol: Cd19, CD19 antigen
- Alias:
- AW495831
- expressed sequence AW495831
- NCBI_Gene: 12478
Mouse Cd19 Predicted Functions
Involved in several processes, including B-1 B cell differentiation; positive regulation of phosphatidylinositol 3-kinase activity; and positive regulation of release of sequestered calcium ion into cytosol. Acts upstream of or within B cell receptor signaling pathway. Located in external side of plasma membrane. Is integral component of plasma membrane. Is expressed in liver and spleen. Human ortholog(s) of this gene implicated in common variable immunodeficiency. Orthologous to human CD19 (CD19 molecule).
Rat Cd19 Target Information
- Target Symbol: Cd19, CD19 molecule
- Alias:
- B-lymphocyte antigen CD19
- CD19 antigen
- LOC365367
- MGC109570
- NCBI_Gene: 365367
Rat Cd19 Predicted Functions
Predicted to be involved in several processes, including B cell activation; B cell receptor signaling pathway; and positive regulation of phosphatidylinositol 3-kinase activity. Predicted to act upstream of or within positive regulation of release of sequestered calcium ion into cytosol. Predicted to be integral component of plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in common variable immunodeficiency. Orthologous to human CD19 (CD19 molecule).
