HGNC ID: 3665
Target Abstract:
Acid fibroblast growth factor (FGF acid), also known as FGF-1, ECGF, and HBGF-1, is a secretory mitogen that can stimulate the proliferation of all cells from the mesoderm and neuroectoderm, ectoderm, and endoderm. It plays a role in development, regeneration, and angiogenesis. Internalized FGF acid can be transferred to the cytoplasm with the help of Hsp90, and then migrate to the nucleus through its two nuclear localization signals. PKC δ Phosphorylated FGF acid can trigger active output into the cytoplasm, where dephosphorylation and degradation occur. Within cells, FGF acid acts as a survival factor by inhibiting p53 activity and promoting apoptosis signaling.
FGF1 Target Infomation Overview
- Target Symbol: FGF1, fibroblast growth factor 1
- Gene Groups: Receptor ligands; Fibroblast growth factor family
- Alias: AFGF; ECGF; ECGFA; ECGFB; HBGF1; ECGF-beta; FGF-alpha; GLIO703
- Previous Names: FGFA
- Alias Names: heparin-binding growth factor 1; endothelial cell growth factor, alpha; endothelial cell growth factor, beta; fibroblast growth factor 1 (acidic)
FGF1, fibroblast growth factor 1 Target Infomation by Species
- Human
- Mouse
- Rat
Human FGF1 Target Information
- Target Symbol: FGF1, fibroblast growth factor 1
- Alias:
- acidic fibroblast growth factor
- AFGF
- beta-endothelial cell growth factor
- ECGF
- ECGF-beta
- ECGFA
- ECGFB
- endothelial cell growth factor
- endothelial cell growth factor, alpha
- endothelial cell growth factor, beta
- FGF-1
- FGF-alpha
- FGFA
- fibroblast growth factor 1 (acidic)
- GLIO703
- HBGF-1
- HBGF1
- heparin-binding growth factor 1
- NCBI_Gene: 2246
- UniProtKB: P05230
Human FGF1 Predicted Functions
Enables S100 protein binding activity; heparin binding activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of MAPK cascade; positive regulation of biosynthetic process; and regulation of endothelial cell migration. Located in cytosol; extracellular space; and nucleoplasm. Implicated in brain ischemia; cleft lip; myocardial infarction; schizophrenia; and urinary bladder cancer. Biomarker of Alzheimer’s disease; endometrial cancer; leiomyoma; ovarian cancer; and transitional cell carcinoma.
Mouse Fgf1 Target Information
- Target Symbol: Fgf1, fibroblast growth factor 1
- Alias:
- Fgf-1
- Fgfa
- fibroblast growth factor 1 (acidic)
- fibroblast growth factor, acidic
- NCBI_Gene: 14164
Mouse Fgf1 Predicted Functions
Predicted to enable several functions, including Hsp70 protein binding activity; S100 protein binding activity; and signaling receptor binding activity. Acts upstream of or within several processes, including organ induction; positive regulation of epithelial cell proliferation; and positive regulation of nitrogen compound metabolic process. Located in extracellular matrix and extracellular space. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in brain ischemia; cleft lip; myocardial infarction; schizophrenia; and urinary bladder cancer. Orthologous to human FGF1 (fibroblast growth factor 1).
Rat Fgf1 Target Information
- Target Symbol: Fgf1, fibroblast growth factor 1
- Alias:
- acidic fibroblast growth factor
- aFGF
- FGF-1
- Fgf2b
- fibroblast growth factor 1 (acidic)
- Fibroblast growth factor 1 (heparin binding)
- fibroblast growth factor 2b
- HBGF-1
- HBGF1
- heparin-binding growth factor 1
- NCBI_Gene: 25317
Rat Fgf1 Predicted Functions
Enables Hsp70 protein binding activity and growth factor activity. Involved in positive regulation of hepatocyte proliferation. Located in cytoplasm and nucleolus. Used to study brain ischemia. Human ortholog(s) of this gene implicated in brain ischemia; cleft lip; myocardial infarction; schizophrenia; and urinary bladder cancer. Orthologous to human FGF1 (fibroblast growth factor 1).
