HGNC ID: 26838
Target Abstract:
TIGIT, known as T-cell immunoglobulin and ITIM structural domain protein, also known as Vsig9, Vstm3, or WUCAM, is a member of the Poliovirus Receptor (PVR)/Nectin family and one of the immunoglobulin superfamily. It consists of an extracellular immunoglobulin (IgV) structural domain, a type I transmembrane structural domain, and an intracellular ITIM and immunoglobulin tyrosine tail (ITT) motif structure.TIGIT is restricted to expression on lymphocytes, with the most abundant expression on CD4+ regulatory T cells, CD4+ follicular helper T cells, CD8+ effector T cells and natural killer (NK) cells .
TIGIT Target Infomation Overview
- Target Symbol: TIGIT, T cell immunoreceptor with Ig and ITIM domains
- Gene Groups: V-set domain containing
- Alias: FLJ39873; DKFZp667A205
- Previous Names: VSIG9; VSTM3
- Alias Names: VSIG9, VSTM3
TIGIT, T cell immunoreceptor with Ig and ITIM domains Target Infomation by Species
- Human
- Mouse
- Rat
Human TIGIT Target Information
- Target Symbol: TIGIT, T cell immunoreceptor with Ig and ITIM domains
- Alias:
- DKFZp667A205
- FLJ39873
- T-cell immunoreceptor with Ig and ITIM domains
- V-set and immunoglobulin domain containing 9
- V-set and immunoglobulin domain-containing protein 9
- V-set and transmembrane domain containing 3
- V-set and transmembrane domain-containing protein 3
- VSIG9
- VSIG9, VSTM3
- VSTM3
- Washington University cell adhesion molecule
- WUCAM
- NCBI_Gene: 201633
- UniProtKB: Q495A1
Human TIGIT Predicted Functions
Enables identical protein binding activity and signaling receptor binding activity. Involved in negative regulation of interleukin-12 production and positive regulation of interleukin-10 production. Acts upstream of or within negative regulation of T cell activation. Located in cell surface.
Mouse Tigit Target Information
- Target Symbol: Tigit, T cell immunoreceptor with Ig and ITIM domains
- Alias:
- ENSMUSG00000071552
- predicted gene, ENSMUSG00000071552
- V-set and transmembrane domain containing 3
- Vstm3
- NCBI_Gene: 100043314
Mouse Tigit Predicted Functions
Enables signaling receptor binding activity. Acts upstream of or within negative regulation of T cell activation. Predicted to be active in cell surface. Orthologous to human TIGIT (T cell immunoreceptor with Ig and ITIM domains).
Rat Tigit Target Information
- Target Symbol: Tigit, T cell immunoreceptor with Ig and ITIM domains
- Alias:
- LOC363784
- RGD1563191
- similar to hypothetical protein
- T-cell immunoreceptor with Ig and ITIM domains
- NCBI_Gene: 363784
- UniProtKB: D3ZTQ2
Rat Tigit Predicted Functions
Predicted to enable identical protein binding activity and signaling receptor binding activity. Predicted to be involved in negative regulation of T cell activation; negative regulation of interleukin-12 production; and positive regulation of interleukin-10 production. Predicted to be integral component of membrane. Predicted to be active in cell surface. Orthologous to human TIGIT (T cell immunoreceptor with Ig and ITIM domains).