HGNC ID: 11926
Target Abstract:
Tumor necrosis factor-associated activation inducible factor (TRANCE), also known as tumor necrosis factor ligand superfamily member 11(TNFSF11), nuclear factor κB receptor activating factor ligand (RANKL), is a member of the TNF superfamily. TRANCE can be expressed in osteoblasts, CD4+ and CD8+T cells, megakaryocytes, bronchial and intestinal epithelial cells. TRANCE plays a central role in immune response and bone morphogenesis. During bone formation and remodeling, TRANCE expressed by osteoblasts, together with M-CSF, induces osteoclast formation and activation, leading to bone resorption, which in turn leads to subsequent bone deposition and remodeling. TRANCE also plays a role in pathological osteoporosis. Inappropriate expression of TRANCE by activated lymphocytes and osteoblasts leads to excessive uptake and deposition in joints and bones. Excess TRANCE is associated with many degenerative bone diseases, such as rheumatoid arthritis and psoriatic arthritis.
TNFSF11 Target Infomation Overview
- Target Symbol: TNFSF11, TNF superfamily member 11
- Gene Groups: CD molecules; Tumor necrosis factor superfamily
- Alias: TRANCE; RANKL; OPGL; ODF; CD254
- Alias Names: tumor necrosis factor (ligand) superfamily, member 11
TNFSF11, TNF superfamily member 11 Target Infomation by Species
- Human
- Mouse
- Rat
Human TNFSF11 Target Information
- Target Symbol: TNFSF11, TNF superfamily member 11
- Alias:
- CD254
- hRANKL2
- ODF
- OPGL
- OPTB2
- osteoclast differentiation factor
- osteoprotegerin ligand
- RANKL
- receptor activator of nuclear factor kappa B ligand
- receptor activator of nuclear factor kappa-B ligand
- sOdf
- TNF-related activation-induced cytokine
- TNLG6B
- TRANCE
- tumor necrosis factor (ligand) superfamily member 11
- tumor necrosis factor (ligand) superfamily, member 11
- tumor necrosis factor ligand 6B
- tumor necrosis factor ligand superfamily member 11
- tumor necrosis factor superfamily member 11
- NCBI_Gene: 8600
- UniProtKB: O14788
Human TNFSF11 Predicted Functions
Enables cytokine activity. Involved in several processes, including positive regulation of MAPK cascade; positive regulation of cell-cell adhesion; and regulation of transcription, DNA-templated. Predicted to be located in extracellular region and plasma membrane. Implicated in autosomal recessive osteopetrosis 2 and osteoporosis. Biomarker of myocardial infarction.
Mouse Tnfsf11 Target Information
- Target Symbol: Tnfsf11, tumor necrosis factor (ligand) superfamily, member 11
- Alias:
- Ly109l
- ODF
- OPGL
- osteoclast differentiation factor
- RANKL
- TNF-related activation-induced cytokine
- Trance
- NCBI_Gene: 21943
Mouse Tnfsf11 Predicted Functions
Enables identical protein binding activity and tumor necrosis factor receptor superfamily binding activity. Involved in several processes, including intracellular signal transduction; positive regulation of secretion by cell; and tumor necrosis factor-mediated signaling pathway. Acts upstream of or within several processes, including animal organ development; cellular response to cytokine stimulus; and positive regulation of intracellular signal transduction. Predicted to be located in cytoplasm; extracellular space; and plasma membrane. Predicted to be integral component of membrane. Is expressed in genitourinary system; hemolymphoid system; hindlimb long bone; and lymphatic system. Used to study autosomal recessive osteopetrosis 2 and osteoporosis. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 2 and osteoporosis. Orthologous to human TNFSF11 (TNF superfamily member 11).
Rat Tnfsf11 Target Information
- Target Symbol: Tnfsf11, TNF superfamily member 11
- Alias:
- LOC103689974
- ODF
- OPGL
- osteoclast differentiation factor
- osteoprotegerin ligand
- RANKL
- receptor activator of nuclear factor kappa B ligand
- receptor activator of nuclear factor kappa-B ligand
- TNF-related activation-induced cytokine
- TRANCE
- tumor necrosis factor (ligand) superfamily, member 11
- tumor necrosis factor ligand superfamily member 11
- tumor necrosis factor superfamily member 11
- NCBI_Gene: 117516
Rat Tnfsf11 Predicted Functions
Predicted to enable cytokine activity; identical protein binding activity; and tumor necrosis factor receptor superfamily binding activity. Involved in several processes, including positive regulation of bone resorption; positive regulation of osteoclast differentiation; and response to immobilization stress. Predicted to be located in extracellular space and plasma membrane. Predicted to be integral component of membrane. Biomarker of mucopolysaccharidosis VI and myocarditis. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 2 and osteoporosis. Orthologous to human TNFSF11 (TNF superfamily member 11).
