HGNC ID: 9922
Target Abstract:
Retinol-binding protein 4 (RBP4) belongs to the apolipoprotein family and is a carrier specific for retinol (vitamin A alcohol) in the blood. It transports retinol from the liver to peripheral tissues. Recently, RBP4 has been recognized as an adipokine that contributes to insulin tolerance in AG4KO mice. It is secreted by adipocytes and signals other cells when blood glucose concentrations fall.Mutations in the RBP4 gene have been associated with autosomal dominant microphthalmia, anophthalmia, and ocular tissue mutilation.
RBP4 Target Infomation Overview
- Target Symbol: RBP4, retinol binding protein 4
- Gene Groups: Lipocalins
- Alias Names: retinol-binding protein 4, plasma
RBP4, retinol binding protein 4 Target Infomation by Species
- Human
- Mouse
- Rat
Human RBP4 Target Information
- Target Symbol: RBP4, retinol binding protein 4
- Alias:
- MCOPCB10
- plasma retinol-binding protein
- PRBP
- RBP
- RDCCAS
- retinol binding protein 4, plasma
- retinol-binding protein 4
- retinol-binding protein 4, interstitial
- NCBI_Gene: 5950
- UniProtKB: P02753
Human RBP4 Predicted Functions
Enables retinol binding activity. Involved in several processes, including gluconeogenesis; positive regulation of insulin secretion; and retinol metabolic process. Located in extracellular space. Implicated in type 2 diabetes mellitus. Biomarker of type 2 diabetes mellitus.
Mouse Rbp4 Target Information
- Target Symbol: Rbp4, retinol binding protein 4, plasma
- Alias:
- Rbp-4
- retinol binding protein 4, cellular
- NCBI_Gene: 19662
Mouse Rbp4 Predicted Functions
Enables retinol binding activity. Involved in several processes, including animal organ development; gluconeogenesis; and negative regulation of cardiac muscle cell proliferation. Acts upstream of or within several processes, including detection of light stimulus involved in visual perception; retinoid metabolic process; and terpenoid transport. Located in extracellular space. Is expressed in several structures, including adipose tissue; brain; genitourinary system; gut; and hindlimb. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human RBP4 (retinol binding protein 4).
Rat Rbp4 Target Information
- Target Symbol: Rbp4, retinol binding protein 4
- Alias:
- plasma retinol-binding protein
- PRBP
- RBP
- RBPA
- retinol binding protein 4, plasma
- retinol-binding protein 4
- NCBI_Gene: 25703
Rat Rbp4 Predicted Functions
Enables retinol binding activity. Involved in response to ethanol and retinol transport. Located in extracellular space. Part of protein-containing complex. Biomarker of obesity and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human RBP4 (retinol binding protein 4).
