HGNC ID: 17866
Target Abstract:
T-cell immunoglobulin domain mucin domain protein-1 (TIM-1), also known as kidney injury factor-1 (KIM-1) and hepatitis A virus cell receptor 1 (HAVcr1), is a member of the TIM gene family and plays a key role in the regulation of immune cell activity, particularly the host immune response to viral infections.TIM-1 is preferentially expressed in Th2 cells and is a stimulatory molecule for T-cell activation. TIM-1 is also involved in allergic reactions, asthma and transplantation tolerance. In humans, TIM-1 acts as a receptor for the entry of several viruses into cells, including hepatitis A virus, dengue virus, and Ebola virus.
HAVCR1 Target Infomation Overview
- Target Symbol: HAVCR1, hepatitis A virus cellular receptor 1
- Gene Groups: CD molecules; V-set domain containing
- Alias: HAVCR-1; TIM-1; TIM1; HAVCR; TIMD1; CD365; KIM1
- Alias Names: T-cell immunoglobulin mucin family member 1; kidney injury molecule 1
HAVCR1, hepatitis A virus cellular receptor 1 Target Infomation by Species
- Human
- Mouse
- Rat
Human HAVCR1 Target Information
- Target Symbol: HAVCR1, hepatitis A virus cellular receptor 1
- Alias:
- CD365
- HAVCR
- HAVCR-1
- kidney injury molecule 1
- KIM-1
- KIM1
- T cell immunoglobin domain and mucin domain protein 1
- T-cell immunoglobulin mucin family member 1
- T-cell immunoglobulin mucin receptor 1
- T-cell membrane protein 1
- TIM
- TIM-1
- TIM1
- TIMD-1
- TIMD1
- NCBI_Gene: 26762
- UniProtKB: Q96D42
Human HAVCR1 Predicted Functions
Enables virus receptor activity. Predicted to be involved in phagocytosis, engulfment and positive regulation of mast cell activation. Predicted to act upstream of or within response to lipopolysaccharide and response to wounding. Part of motile cilium. Implicated in atopic dermatitis. Biomarker of several diseases, including hydronephrosis; hyperuricemia; kidney disease (multiple); relapsing-remitting multiple sclerosis; and vesicoureteral reflux.
Mouse Havcr1 Target Information
- Target Symbol: Havcr1, hepatitis A virus cellular receptor 1
- Alias:
- AI503787
- expressed sequence AI503787
- KIM-1
- T-cell immunoglobulin and mucin domain containing 1
- TIM-1
- Tim1
- Timd1
- NCBI_Gene: 171283
Mouse Havcr1 Predicted Functions
Enables phosphatidylserine binding activity. Acts upstream of or within positive regulation of mast cell activation; response to lipopolysaccharide; and response to wounding. Located in brush border and cell surface. Is expressed in brain; dorsal aorta; liver; lung; and reproductive system. Human ortholog(s) of this gene implicated in atopic dermatitis. Orthologous to human HAVCR1 (hepatitis A virus cellular receptor 1).
Rat Havcr1 Target Information
- Target Symbol: Havcr1, hepatitis A virus cellular receptor 1
- Alias:
- HAVcr-1
- hepatitis A virus cellular receptor 1 homolog
- kidney injury molecule 1
- KIM-1
- Kim1
- t cell immunoglobulin and mucin domain-containing protein 1
- TIMD-1
- NCBI_Gene: 286934
Rat Havcr1 Predicted Functions
Predicted to enable phosphatidylserine binding activity and virus receptor activity. Involved in several processes, including phagocytosis, engulfment; response to mycotoxin; and response to testosterone. Located in several cellular components, including apical plasma membrane; cell surface; and phagocytic vesicle. Biomarker of colitis; hypertension; kidney failure (multiple); and proteinuria (multiple). Human ortholog(s) of this gene implicated in atopic dermatitis. Orthologous to human HAVCR1 (hepatitis A virus cellular receptor 1).
