HGNC ID: 14900
Target Abstract:
Interleukin 22 (IL-22) is a member of the IL-10 family or IL-10 superfamily (including IL-19, IL-20, IL-24, and IL-26) of cytokines, a class of potent regulators of cellular inflammatory responses. It shares the use of IL-10R2 in cell signaling with other members of this family, IL-10, IL-26, IL-28A/B, and IL-29.IL-22 is produced by activated DCs and T cells and initiates the innate immune response against pathogenic bacteria, especially those originating from epithelial cells, such as respiratory and intestinal epithelial cells. Patients with psoriasis exhibit strongly elevated plasma levels of IL-22, which correlates with the severity of the disease. In hepatitis mediated by concomitant cutanea lectin A (ConA)-induced T cells, IL-22 may play a protective role as a survival factor for hepatocytes. In contrast to IFN-γ and IL-17, large amounts of IL-22 are present in the blood of patients with Crohn’s disease.
IL22 Target Infomation Overview
- Target Symbol: IL22, interleukin 22
- Gene Groups: Interleukins
- Alias: ILTIF; IL-21; zcyto18; IL-TIF; IL-D110; TIFa; TIFIL-23; IL-22; MGC79382; MGC79384
- Alias Names: IL-10-related T-cell-derived inducible factor
IL22, interleukin 22 Target Infomation by Species
- Human
- Mouse
- Rat
Human IL22 Target Information
- Target Symbol: IL22, interleukin 22
- Alias:
- cytokine Zcyto18
- IL-10-related T-cell-derived inducible factor
- IL-10-related T-cell-derived-inducible factor
- IL-21
- IL-22
- IL-D110
- IL-TIF
- IL21
- ILTIF
- interleukin 21
- interleukin-22
- MGC79382
- MGC79384
- TIFa
- TIFIL-23
- zcyto18
- NCBI_Gene: 50616
- UniProtKB: Q9GZX6
Human IL22 Predicted Functions
Predicted to enable cytokine activity. Predicted to be involved in response to glucocorticoid and signal transduction. Predicted to be located in extracellular region. Biomarker of asthma; rhinitis; and tuberculosis.
Mouse Il22 Target Information
- Target Symbol: Il22, interleukin 22
- Alias:
- IL-22
- IL-TIF
- Iltif
- interleukin 10-related T cell-derived inducible factor
- NCBI_Gene: 50929
Mouse Il22 Predicted Functions
Predicted to enable cytokine activity. Acts upstream of or within several processes, including negative regulation of inflammatory response; reactive oxygen species metabolic process; and regulation of tyrosine phosphorylation of STAT protein. Predicted to be located in extracellular space. Is expressed in retina and skin. Used to study liposarcoma. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IL22 (interleukin 22).
Rat Il22 Target Information
- Target Symbol: Il22, interleukin 22
- Alias:
- If2b1
- interferon 2b1
- interleukin-22
- LOC500836
- RGD1561292
- similar to TIF alpha protein
- NCBI_Gene: 500836
Rat Il22 Predicted Functions
Involved in response to glucocorticoid. Located in extracellular space. Used to study asthma and myocarditis. Orthologous to human IL22 (interleukin 22).
